The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Centromere and telomere movements during early meiotic prophase of mouse and man are associated with the onset of chromosome pairing.
Open accessAbstract
The preconditions and early steps of meiotic chromosome pairing were studied by fluorescence in situ hybridization (FISH) with chromosome-specific DNA probes to mouse and human testis tissue sections. Premeiotic pairing of homologous chromosomes was not detected in spermatogonia of the two species. FISH with centromere- and telomere-specific DNA probes in combination with immunostaining (IS) of synaptonemal complex (SC) proteins to testis sections of prepuberal mice at days 4-12 post partum was performed to study sequentially the meiotic pairing process. Movements of centromeres and then telomeres to the nuclear envelope, and of telomeres along the nuclear envelope leading to the formation of a chromosomal bouquet were detected during mouse prophase. At the bouquet stage, pairing of a mouse chromosome-8-specific probe was observed. SC-IS and simultaneous telomere FISH revealed that axial element proteins appear as large aggregates in mouse meiocytes when telomeres are attached to the nuclear envelope. Axial element formation initiates during tight telomere clustering and transverse filament-IS indicated the initiation of synapsis during this stage. Comparison of telomere and centromere distribution patterns of mouse and human meiocytes revealed movements of centromeres and then telomeres to the nuclear envelope and subsequent bouquet formation as conserved motifs of the pairing process. Chromosome painting in human spermatogonia revealed compacted, largely mutually exclusive chromosome territories. The territories developed into long, thin threads at the onset of meiotic prophase. Based on these results a unified model of the pairing process is proposed.
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Cites
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Telomere-Led Premeiotic Chromosome Movement in Fission Yeast
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Self-citation
Cited by
Loss of the Suv39h Histone Methyltransferases Impairs Mammalian Heterochromatin and Genome Stability
Peters, A. H. F. M., O'Carroll, D., Scherthan, H., Mechtler, K., Sauer, S., Schöfer, C., Weipoltshammer, K., Pagani, M., Lachner, M., Kohlmaier, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00542-6 · Cited by 1,766
Self-citationMeiotic Chromosomes: Integrating Structure and Function
Zickler, D., & Kleckner, N. (1999) · Annual Review of Genetics · doi:10.1146/annurev.genet.33.1.603 · Cited by 1,255
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Self-citationMouse MutS-like protein Msh5 is required for proper chromosome synapsis in male and female meiosis
de Vries, S. S., Baart, E. B., Dekker, M., Siezen, A., de Rooij, D. G., de Boer, P., & te Riele, H. (1999) · Genes & Development · doi:10.1101/gad.13.5.523 · Cited by 365
Bass, H. W., Marshall, W. F., Sedat, J. W., Agard, D. A., & Cande, W. Z. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.137.1.5 · Cited by 294
Metadata
- Authors
- Scherthan, H., Weich, S., Schwegler, H., Heyting, C., Härle, M., & Cremer, T.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1996-09-01
- Volume
- 134
- Issue
- 5
- Pages
- 1109-1125
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W1999718358
- Cited by
- 431
- References
- 44
- FWCI
- 7.67
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Centromere and telomere movements during early meiotic prophase of mouse and man are associated with the onset of chromosome pairing. https://app.cochat.ai/papers/10.1083/jcb.134.5.1109
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- Scherthan, H., Weich, S., Schwegler, H., Heyting, C., Härle, M., & Cremer, T. (1996). Centromere and telomere movements during early meiotic prophase of mouse and man are associated with the onset of chromosome pairing. The Journal of cell biology. https://doi.org/10.1083/jcb.134.5.1109
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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