The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Characterization of a premeiotic germ cell-specific cytoplasmic protein encoded by Stra8, a novel retinoic acid-responsive gene.
Open accessAbstract
The full-length cDNA corresponding to Stra8, a novel gene inducible by retinoic acid (RA) in P19 embryonal carcinoma cells, has been isolated and shown to encode a 45-kD protein. Both Stra8 mRNA and protein were induced in cells treated by all-trans and 9-cis retinoic acids. Two-dimensional gel analysis and dephosphorylation experiments revealed that the two stereoisomers of RA differentially regulate the phosphorylation status of the Stra8 protein, which was shown to exist in differently phosphorylated forms. Subcellular fractionation and immunocytochemistry studies showed that the Stra8 protein is cytoplasmic. During mouse embryogenesis, Stra8 expression was restricted to the male developing gonads, and in adult mice, the expression of Stra8 was restricted to the premeiotic germ cells. Thus, Stra8 protein may play a role in the premeiotic phase of spermatogenesis.
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Cites
The nuclear receptor superfamily: the second decade
Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90199-x · Cited by 6,964
Self-citationA decade of molecular biology of retinoic acid receptors
Chambon, P. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.9.8801176 · Cited by 2,889
Self-citation9-cis retinoic acid is a high affinity ligand for the retinoid X receptor
Heyman, R. A., Mangelsdorf, D. J., Dyck, J. A., Stein, R. B., Eichele, G., Evans, R. M., & Thaller, C. (1992) · Cell · doi:10.1016/0092-8674(92)90479-v · Cited by 1,780
Multiplicity generates diversity in the retinoic acid signalling pathways
Leid, M., Kastner, P., & Chambon, P. (1992) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(92)90014-z · Cited by 821 · cited 1×
“The three retinoic acid (RA) 1 receptors (RARtx, 13, and ~/) bind all-trans (T-RA) and 9-cis RA (9C-RA), while the three retinoid X receptors (RXRet, 13, and ~/) bind only 9C-RA (for review see Chambon, 1994, 1996; Leid et al., 1992; Mangelsdorf et al., 1994, 1995).”
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Cited by
Retinoic acid regulates sex-specific timing of meiotic initiation in mice
Koubova, J., Menke, D. B., Zhou, Q., Capel, B., Griswold, M. D., & Page, D. C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510813103 · Cited by 941
Spermatogenesis: The Commitment to Meiosis
Griswold, M. D. (2016) · Physiological Reviews · doi:10.1152/physrev.00013.2015 · Cited by 825
Survey Sequencing and Comparative Analysis of the Elephant Shark (Callorhinchus milii) Genome
Venkatesh, B., Kirkness, E. F., Loh, Y.-H., Halpern, A. L., Lee, A. P., Johnson, J., Dandona, N., Viswanathan, L. D., Tay, A., Venter, J. C., et al. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050101 · Cited by 309
Bouillet, P., Sapin, V., Chazaud, C., Messaddeq, N., Décimo, D., Dollé, P., & Chambon, P. (1997) · Mechanisms of Development · doi:10.1016/s0925-4773(97)00039-7 · Cited by 209
Self-citationSleutels, F., Soochit, W., Bartkuhn, M., Heath, H., Dienstbach, S., Bergmaier, P., Franke, V., Rosa-Garrido, M., van de Nobelen, S., Caesar, L., et al. (2012) · Epigenetics & Chromatin · doi:10.1186/1756-8935-5-8 · Cited by 96
Metadata
- Authors
- Oulad-Abdelghani, M., Bouillet, P., Décimo, D., Gansmuller, A., Heyberger, S., Dollé, P., Bronner, S., Lutz, Y., & Chambon, P.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1996-10-15
- Volume
- 135
- Issue
- 2
- Pages
- 469-477
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2144649761
- Cited by
- 342
- References
- 4
- FWCI
- 1.76
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Characterization of a premeiotic germ cell-specific cytoplasmic protein encoded by Stra8, a novel retinoic acid-responsive gene. https://app.cochat.ai/papers/10.1083/jcb.135.2.469
- The paper
- Oulad-Abdelghani, M., Bouillet, P., Décimo, D., Gansmuller, A., Heyberger, S., Dollé, P., Bronner, S., Lutz, Y., & Chambon, P. (1996). Characterization of a premeiotic germ cell-specific cytoplasmic protein encoded by Stra8, a novel retinoic acid-responsive gene. The Journal of cell biology. https://doi.org/10.1083/jcb.135.2.469
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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