The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway
Open accessAbstract
Several genetic forms of human dwarfism have been linked to activating mutations in FGF receptor 3, indicating that FGF signaling has a critical role in chondrocyte maturation and skeletal development. However, the mechanisms through which FGFs affect chondrocyte proliferation and differentiation remain poorly understood. We show here that activation of FGF signaling inhibits chondrocyte proliferation both in a rat chondrosarcoma (RCS) cell line and in primary murine chondrocytes. FGF treatment of RCS cells induces phosphorylation of STAT-1, its translocation to the nucleus, and an increase in the expression of the cell-cycle inhibitor p21WAF1/CIP1. We have used primary chondrocytes from STAT-1 knock-out mice to provide genetic evidence that STAT-1 function is required for the FGF mediated growth inhibition. Furthermore, FGF treatment of metatarsal rudiments from wild-type and STAT-1(-/-) murine embryos produces a drastic impairment of chondrocyte proliferation and bone development in wild-type, but not in STAT-1(-/-) rudiments. We propose that STAT-1 mediated down regulation of chondrocyte proliferation by FGF signaling is an homeostatic mechanism which ensures harmonious bone development and morphogenesis.
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Cites
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Self-citation
Cited by
Cell Signaling by Receptor Tyrosine Kinases
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Cell Signaling by Receptor Tyrosine Kinases
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The Fibroblast Growth Factor signaling pathway
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The role of STATs in transcriptional control and their impact on cellular function
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Genetic Control of Bone Formation
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Metadata
- Authors
- Sahni, M., Ambrosetti, D.-C., Mansukhani, A., Gertner, R., Levy, D., & Basilico, C.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1999-06-01
- Volume
- 13
- Issue
- 11
- Pages
- 1361-1366
- ISSN
- 0890-9369 (ISSN-L)
- OpenAlex
- W2115675418
- Cited by
- 375
- References
- 26
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Sahni, M., Ambrosetti, D.-C., Mansukhani, A., Gertner, R., Levy, D., & Basilico, C. (1999). FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway. Genes & Development. https://doi.org/10.1101/gad.13.11.1361
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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