The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Visualization of the Dynamics of Synaptic Vesicle and Plasma Membrane Proteins in Living Axons
Open accessAbstract
Newly synthesized membrane proteins are transported by fast axonal flow to their targets such as the plasma membrane and synaptic vesicles. However, their transporting vesicles have not yet been identified. We have successfully visualized the transporting vesicles of plasma membrane proteins, synaptic vesicle proteins, and the trans-Golgi network residual proteins in living axons at high resolution using laser scan microscopy of green fluorescent protein-tagged proteins after photobleaching. We found that all of these proteins are transported by tubulovesicular organelles of various sizes and shapes that circulate within axons from branch to branch and switch the direction of movement. These organelles are distinct from the endosomal compartments and constitute a new entity of membrane organelles that mediate the transport of newly synthesized proteins from the trans-Golgi network to the plasma membrane.
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“This technique enabled the visualization of organelle transport in living axons and led to the discovery of the kinesin motor protein (Brady et al., 1985; Vale et al., 1985 ).”
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Cited by
Molecular motors and mechanisms of directional transport in neurons
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Dynamic Aspects of CNS Synapse Formation
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Unitary Assembly of Presynaptic Active Zones from Piccolo-Bassoon Transport Vesicles
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Synaptic vesicle recycling: steps and principles
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Metadata
- Authors
- Nakata, T., Terada, S., & Hirokawa, N.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 1998-02-09
- Volume
- 140
- Issue
- 3
- Pages
- 659-674
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W1981415432
- Cited by
- 314
- References
- 61
- FWCI
- 8.54
- Type
- journal article
- Language
- en
- Open access
- green
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- Nakata, T., Terada, S., & Hirokawa, N. (1998). Visualization of the Dynamics of Synaptic Vesicle and Plasma Membrane Proteins in Living Axons. The Journal of Cell Biology. https://doi.org/10.1083/jcb.140.3.659
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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