Dynamic Aspects of CNS Synapse Formation
Open accessAbstract
The mammalian central nervous system (CNS) requires the proper formation of exquisitely precise circuits to function correctly. These neuronal circuits are assembled during development by the formation of synaptic connections between thousands of differentiating neurons. Proper synapse formation during childhood provides the substrate for cognition, whereas improper formation or function of these synapses leads to neurodevelopmental disorders, including mental retardation and autism. Recent work has begun to identify some of the early cellular events in synapse formation as well as the molecular signals that initiate this process. However, despite the wealth of information published on this topic in the past few years, some of the most fundamental questions about how, whether, and where glutamatergic synapses form in the mammalian CNS remain unanswered. This review focuses on the dynamic aspects of the early cellular and molecular events in the initial assembly of glutamatergic synapses in the mammalian CNS.
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Proper synapse formation during childhood provides a substrate for cognition, whereas improper formation or functionality leads to neuro-developmental disorders including mental retardation and autism.
“Proper synapse formation during childhood provides a substrate for cognition, whereas improper formation or functionality leads to neuro-developmental disorders including mental retardation and autism”
From Human Brain/Cloud Interface (2019) · cites this paper as Mcallister, 2007
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- Authors
- McAllister, A. K.
- Affiliations
- University of California, Davis (US)
- Corresponding author
- McAllister, A. Kimberley
- Venue
- Annual Review of Neuroscience
- Publisher
- Annual Reviews
- Published
- 2007-07-01
- Volume
- 30
- Issue
- 1
- Pages
- 425-450
- ISSN
- 0147-006X (ISSN-L)
- 1545-4126
- PMC
- PMC3251656
- OpenAlex
- W2148673800
- Cited by
- 368
- References
- 3
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 12 · 2023: 8 · 2022: 16 · 2021: 13 · 2020: 13 · 2019: 12 · 2018: 21 · 2017: 21 · 2016: 17 · 2015: 28 · 2014: 13 · 2013: 29 · 2012: 25
- FWCI
- 2.54
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annual Review of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Alfred P. Sloan Foundation
- John Merck Fund
- National Eye Institute (R01EY013584)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- synaptogenesis, glutamatergic synapses, central nervous system development, neurodevelopmental disorders, autism spectrum disorder, intellectual disability, synaptic signaling, synapse maturation
- MeSH terms
- Animals, Cell Differentiation, Central Nervous System, Humans, Nerve Tissue Proteins, Neural Pathways, Receptors, Cell Surface, Synapses, Synaptic Membranes, Presynaptic Terminals, Glutamic Acid
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