The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Caveolin-1 and -2 in the Exocytic Pathway of MDCK Cells
Open accessAbstract
Abstract. We have studied the biosynthesis and transport of the endogenous caveolins in MDCK cells. We show that in addition to homooligomers of caveolin-1, heterooligomeric complexes of caveolin-1 and -2 are formed in the ER. The oligomers become larger, increasingly detergent insoluble, and phosphorylated on caveolin-2 during transport to the cell surface. In the TGN caveolin-1/-2 heterooligomers are sorted into basolateral vesicles, whereas larger caveolin-1 homooligomers are targeted to the apical side. Caveolin-1 is present on both the apical and basolateral plasma membrane, whereas caveolin-2 is enriched on the basolateral surface where caveolae are present. This suggests that caveolin-1 and -2 heterooligomers are involved in caveolar biogenesis in the basolateral plasma membrane. Anti–caveolin-1 antibodies inhibit the apical delivery of influenza virus hemagglutinin without affecting basolateral transport of vesicular stomatitis virus G protein. Thus, we suggest that caveolin-1 homooligomers play a role in apical transport.
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Citations
Cites
Functional rafts in cell membranes
Simons, K., & Ikonen, E. (1997) · Nature · doi:10.1038/42408 · Cited by 9,757
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Rietveld, A., & Simons, K. (1998) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/s0304-4157(98)00019-7 · Cited by 513
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Metadata
- Authors
- Scheiffele, P., Verkade, P., Fra, A. M., Virta, H., Simons, K., & Ikonen, E.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 1998-02-23
- Volume
- 140
- Issue
- 4
- Pages
- 795-806
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2106631104
- Cited by
- 302
- References
- 1
- FWCI
- 9.48
- Type
- journal article
- Language
- en
- Open access
- green
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- Scheiffele, P., Verkade, P., Fra, A. M., Virta, H., Simons, K., & Ikonen, E. (1998). Caveolin-1 and -2 in the Exocytic Pathway of MDCK Cells. The Journal of Cell Biology. https://doi.org/10.1083/jcb.140.4.795
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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