The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The Pathway of Membrane Fusion Catalyzed by Influenza Hemagglutinin: Restriction of Lipids, Hemifusion, and Lipidic Fusion Pore Formation
Open accessAbstract
The mechanism of bilayer unification in biological fusion is unclear. We reversibly arrested hemagglutinin (HA)-mediated cell–cell fusion right before fusion pore opening. A low-pH conformation of HA was required to form this intermediate and to ensure fusion beyond it. We present evidence indicating that outer monolayers of the fusing membranes were merged and continuous in this intermediate, but HA restricted lipid mixing. Depending on the surface density of HA and the membrane lipid composition, this restricted hemifusion intermediate either transformed into a fusion pore or expanded into an unrestricted hemifusion, without pores but with unrestricted lipid mixing. Our results suggest that restriction of lipid flux by a ring of activated HA is necessary for successful fusion, during which a lipidic fusion pore develops in a local and transient hemifusion diaphragm.
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Citations
Cites
Structure of influenza haemagglutinin at the pH of membrane fusion
Bullough, P. A., Hughson, F. M., Skehel, J. J., & Wiley, D. C. (1994) · Nature · doi:10.1038/371037a0 · Cited by 1,564
Chanturiya, A., Chernomordik, L. V., & Zimmerberg, J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14423 · Cited by 201
Self-citation
Cited by
Receptor Binding and Membrane Fusion in Virus Entry: The Influenza Hemagglutinin
Skehel, J. J., & Wiley, D. C. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.531 · Cited by 2,706
Membrane Fusion and Exocytosis
Jahn, R., & Südhof, T. C. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.863 · Cited by 1,259
Chernomordik, L. V., & Kozlov, M. M. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1455 · Cited by 1,037
Self-citationStructure of a flavivirus envelope glycoprotein in its low‐pH‐induced membrane fusion conformation
Bressanelli, S., Stiasny, K., Allison, S. L., Stura, E. A., Duquerroy, S., Lescar, J., Heinz, F. X., & Rey, F. A. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600064 · Cited by 593
Synaptotagmin: A Ca2+ sensor that triggers exocytosis?
Chapman, E. R. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm855 · Cited by 485
Metadata
- Authors
- Chernomordik, L. V., Frolov, V. A., Leikina, E., Bronk, P., & Zimmerberg, J.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 1998-03-23
- Volume
- 140
- Issue
- 6
- Pages
- 1369-1382
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2015611396
- Cited by
- 363
- References
- 2
- FWCI
- 8.89
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: The Pathway of Membrane Fusion Catalyzed by Influenza Hemagglutinin: Restriction of Lipids, Hemifusion, and Lipidic Fusion Pore Formation. https://app.cochat.ai/papers/10.1083/jcb.140.6.1369
- The paper
- Chernomordik, L. V., Frolov, V. A., Leikina, E., Bronk, P., & Zimmerberg, J. (1998). The Pathway of Membrane Fusion Catalyzed by Influenza Hemagglutinin: Restriction of Lipids, Hemifusion, and Lipidic Fusion Pore Formation. The Journal of Cell Biology. https://doi.org/10.1083/jcb.140.6.1369
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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