The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Direct Interaction of CASK/LIN-2 and Syndecan Heparan Sulfate Proteoglycan and Their Overlapping Distribution in Neuronal Synapses
Open accessAbstract
CASK, the rat homolog of a gene (LIN-2) required for vulval differentiation in Caenorhabditis elegans, is expressed in mammalian brain, but its function in neurons is unknown. CASK is distributed in a punctate somatodendritic pattern in neurons. By immunogold EM, CASK protein is concentrated in synapses, but is also present at nonsynaptic membranes and in intracellular compartments. This immunolocalization is consistent with biochemical studies showing the presence of CASK in soluble and synaptosomal membrane fractions and its enrichment in postsynaptic density fractions of rat brain. By yeast two-hybrid screening, a specific interaction was identified between the PDZ domain of CASK and the COOH terminal tail of syndecan-2, a cell surface heparan sulfate proteoglycan (HSPG). The interaction was confirmed by coimmunoprecipitation from heterologous cells. In brain, syndecan-2 localizes specifically at synaptic junctions where it shows overlapping distribution with CASK, consistent with an interaction between these proteins in synapses. Cell surface HSPGs can bind to extracellular matrix proteins, and are required for the action of various heparin-binding polypeptide growth/differentiation factors. The synaptic localization of CASK and syndecan suggests a potential role for these proteins in adhesion and signaling at neuronal synapses.
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Cited by
Functions of Cell Surface Heparan Sulfate Proteoglycans
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Self-citationStargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms
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Südhof, T. C. (2012) · Neuron · doi:10.1016/j.neuron.2012.06.012 · Cited by 1,062
Metadata
- Authors
- Hsueh, Y.-P., Yang, F.-C., Kharazia, V., Naisbitt, S., Cohen, A. R., Weinberg, R. J., & Sheng, M.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 1998-07-13
- Volume
- 142
- Issue
- 1
- Pages
- 139-151
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2077576116
- Cited by
- 337
- References
- 46
- FWCI
- 10.88
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Direct Interaction of CASK/LIN-2 and Syndecan Heparan Sulfate Proteoglycan and Their Overlapping Distribution in Neuronal Synapses. https://app.cochat.ai/papers/10.1083/jcb.142.1.139
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- Hsueh, Y.-P., Yang, F.-C., Kharazia, V., Naisbitt, S., Cohen, A. R., Weinberg, R. J., & Sheng, M. (1998). Direct Interaction of CASK/LIN-2 and Syndecan Heparan Sulfate Proteoglycan and Their Overlapping Distribution in Neuronal Synapses. The Journal of Cell Biology. https://doi.org/10.1083/jcb.142.1.139
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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