The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Syndecans: multifunctional cell-surface co-receptors
Open accessAbstract
This review will summarize our current state of knowledge of the structure, biochemical properties and functions of syndecans, a family of transmembrane heparan sulphate proteoglycans. Syndecans bind a variety of extracellular ligands via their covalently attached heparan sulphate chains. Syndecans have been proposed to play a role in a variety of cellular functions, including cell proliferation and cell–matrix and cell–cell adhesion. Syndecan expression is highly regulated and is cell-type- and developmental-stage-specific. The main function of syndecans appears to be to modulate the ligand-dependent activation of primary signalling receptors at the cell surface. Principal functions of the syndecan core proteins are to target the heparan sulphate chains to the appropriate plasma-membrane compartment and to interact with components of the actin-based cytoskeleton. Several functions of the syndecans, including syndecan oligomerization and actin cytoskeleton association, have been localized to specific structural domains of syndecan core proteins.
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Cited by
Functions of Cell Surface Heparan Sulfate Proteoglycans
Bernfield, M., Götte, M., Park, P. W., Reizes, O., Fitzgerald, M. L., Lincecum, J., & Zako, M. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.729 · Cited by 2,688
The extracellular matrix in development and morphogenesis: A dynamic view
Rozario, T., & DeSimone, D. W. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2009.10.026 · Cited by 1,451
Spectrin and Ankyrin-Based Pathways: Metazoan Inventions for Integrating Cells Into Tissues
Bennett, V., & Baines, A. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1353 · Cited by 930
Proteoglycans in the Developing Brain: New Conceptual Insights for Old Proteins
Bandtlow, C. E., & Zimmermann, D. R. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1267 · Cited by 632
Heparan Sulfate Proteoglycan Is a Mechanosensor on Endothelial Cells
Florian, J. A., Kosky, J. R., Ainslie, K., Pang, Z., Dull, R. O., & Tarbell, J. M. (2003) · Circulation Research · doi:10.1161/01.res.0000101744.47866.d5 · Cited by 615
Metadata
- Authors
- CAREY, D. J.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1997-10-01
- Volume
- 327
- Issue
- 1
- Pages
- 1-16
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W1853807720
- Cited by
- 691
- References
- 6
- FWCI
- 15.11
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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