The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Regulated Actin Cytoskeleton Assembly at Filopodium Tips Controls Their Extension and Retraction
Open accessAbstract
The extension and retraction of filopodia in response to extracellular cues is thought to be an important initial step that determines the direction of growth cone advance. We sought to understand how the dynamic behavior of the actin cytoskeleton is regulated to produce extension or retraction. By observing the movement of fiduciary marks on actin filaments in growth cones of a neuroblastoma cell line, we found that filopodium extension and retraction are governed by a balance between the rate of actin cytoskeleton assembly at the tip and retrograde flow. Both assembly and flow rate can vary with time in a single filopodium and between filopodia in a single growth cone. Regulation of assembly rate is the dominant factor in controlling filopodia behavior in our system.
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Cites
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Self-citationACTIN AND ACTIN-BINDING PROTEINS. A CRITICAL EVALUATION OF MECHANISMS AND FUNCTIONS
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Cytoskeletal dynamics and nerve growth
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Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton
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Actin microfilament dynamics in locomoting cells
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Self-citationInduction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP
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Cited by
Traction Dynamics of Filopodia on Compliant Substrates
Chan, C. E., & Odde, D. J. (2008) · Science · doi:10.1126/science.1163595 · Cited by 936
Cytoskeletal Dynamics and Transport in Growth Cone Motility and Axon Guidance
Dent, E. W., & Gertler, F. B. (2003) · Neuron · doi:10.1016/s0896-6273(03)00633-0 · Cited by 893
The actin cytoskeleton and actin-based motility
Svitkina, T. (2018) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018267 · Cited by 761
Actin Cytoskeleton Regulation in Neuronal Morphogenesis and Structural Plasticity
Luo, L. (2002) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.18.031802.150501 · Cited by 658
Physicochemical modelling of cell signalling pathways
Aldridge, B. B., Burke, J. M., Lauffenburger, D. A., & Sorger, P. K. (2006) · Nature Cell Biology · doi:10.1038/ncb1497 · Cited by 592
Metadata
- Authors
- Mallavarapu, A., & Mitchison, T.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 1999-09-06
- Volume
- 146
- Issue
- 5
- Pages
- 1097-1106
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2105315411
- Cited by
- 406
- References
- 39
- FWCI
- 4.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Mallavarapu, A., & Mitchison, T. (1999). Regulated Actin Cytoskeleton Assembly at Filopodium Tips Controls Their Extension and Retraction. The Journal of Cell Biology. https://doi.org/10.1083/jcb.146.5.1097
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
