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Cited by 360Neurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration Mechanisms

The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.

Axonal Control of Oligodendrocyte Development

Open access
Barres, Ben A., Raff, Martin C.·1999·The Journal of Cell Biology
DOI 10.1083/jcb.147.6.1123PMC PMC2168096
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Abstract

How are the numbers of different cell types matched together during tissue development? The nervous system has provided an excellent model system for understanding this question as it contains two main classes of cell types, neurons and glia. Presynaptic neurons are believed to be precisely matched

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Crossref · 10.1083/jcb.147.6.1123

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Figure 1 A model for how oligodendrocyte number is matched to axonal surface area. Once an OPC stops dividing and differentiates into an oligodendrocyte (left side of figure), it has 2–3 d to contact an unmyelinated region of axon, which provides a new signal that the cell requires for continued survival. Astrocyte-derived signals, such as PDGF, can promote the survival of newly formed oligodendrocytes for at least 2 d (middle of figure). But as the newly formed oligodendrocytes undergo further maturation (right side of figure), they lose responsiveness to these astrocyte-derived signals and require an axonal signal to survive. Those that fail to contact an axon by 3 d after generation undergo apoptosis.
Figure 1 A model for how oligodendrocyte number is matched to axonal surface area. Once an OPC stops dividing and differentiates into an oligodendrocyte (left side of figure), it has 2–3 d to contact an unmyelinated region of axon, which provides a new signal that the cell requires for continued survival. Astrocyte-derived signals, such as PDGF, can promote the survival of newly formed oligodendrocytes for at least 2 d (middle of figure). But as the newly formed oligodendrocytes undergo further maturation (right side of figure), they lose responsiveness to these astrocyte-derived signals and require an axonal signal to survive. Those that fail to contact an axon by 3 d after generation undergo apoptosis.CC BY-NC-SA · PubMed Central

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Show all 69 references

Research works printed but not linked: 2

  1. Barres, 1993, Does oligodendrocyte survival depend on axons?, Curr. Biol., 3, 489, 10.1016/0960-9822(93)90039-Q · DOI
  2. Purves, 1988, Body and BrainA Trophic Theory of Neural Connections

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Metadata

Authors
Barres, B. A., & Raff, M. C.
Affiliations
  • Stanford Medicine (US)
  • MRC Laboratory for Molecular Cell Biology (GB)
ORCID
Barres, Ben A.
Venue
The Journal of Cell Biology
Publisher
Rockefeller University Press
Published
1999-12-13
Volume
147
Issue
6
Pages
1123-1128
ISSN
  • 0021-9525 (ISSN-L)
  • 1540-8140
DOI
10.1083/jcb.147.6.1123
PMC
PMC2168096
OpenAlex
W1993097534
Cited by
360
References
69
Citations by year
2026: 2 · 2025: 6 · 2024: 28 · 2023: 5 · 2022: 9 · 2021: 13 · 2020: 16 · 2019: 8 · 2018: 12 · 2017: 14 · 2016: 9 · 2015: 10 · 2014: 17 · 2013: 17 · 2012: 9
FWCI
1.28
Type
journal article
Language
en
Open access
Licence
cc-by-nc-sa
Locations
  • The Journal of Cell Biology (publishedVersion)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
oligodendrocyte development, axon-glia interaction, brain development, glial differentiation
MeSH terms
Animals, Axons, Cell Count, Cell Differentiation, Cell Division, Cell Survival, Myelin Sheath, Oligodendroglia, Neuregulins

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