The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Reciprocal Role of ERK and Nf-κb Pathways in Survival and Activation of Osteoclasts
Open accessAbstract
To examine the role of mitogen-activated protein kinase and nuclear factor kappa B (NF-κB) pathways on osteoclast survival and activation, we constructed adenovirus vectors carrying various mutants of signaling molecules: dominant negative Ras (RasDN), constitutively active MEK1 (MEKCA), dominant negative IκB kinase 2 (IKKDN), and constitutively active IKK2 (IKKCA). Inhibiting ERK activity by RasDN overexpression rapidly induced the apoptosis of osteoclast-like cells (OCLs) formed in vitro, whereas ERK activation after the introduction of MEKCA remarkably lengthened their survival by preventing spontaneous apoptosis. Neither inhibition nor activation of ERK affected the bone-resorbing activity of OCLs. Inhibition of NF-κB pathway with IKKDN virus suppressed the pit-forming activity of OCLs and NF-κB activation by IKKCA expression upregulated it without affecting their survival. Interleukin 1α (IL-1α) strongly induced ERK activation as well as NF-κB activation. RasDN virus partially inhibited ERK activation, and OCL survival promoted by IL-1α. Inhibiting NF-κB activation by IKKDN virus significantly suppressed the pit-forming activity enhanced by IL-1α. These results indicate that ERK and NF-κB regulate different aspects of osteoclast activation: ERK is responsible for osteoclast survival, whereas NF-κB regulates osteoclast activation for bone resorption.
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Cites
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Cited by
The molecular understanding of osteoclast differentiation
Asagiri, M., & Takayanagi, H. (2007) · Bone · doi:10.1016/j.bone.2006.09.023 · Cited by 1,363
Self-citationM-CSF, TNFα and RANK ligand promote osteoclast survival by signaling through mTOR/S6 kinase
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Reactive oxygen species mediate RANK signaling in osteoclasts
Ha, H., Bok Kwak, H., Woong Lee, S., Mi Jin, H., Kim, H.-M., Kim, H.-H., & Hee Lee, Z. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.07.035 · Cited by 347
Tanaka, S., Nakamura, K., Takahasi, N., & Suda, T. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00327.x · Cited by 320
Self-citationItoh, K., Udagawa, N., Katagiri, T., Iemura, S., Ueno, N., Yasuda, H., Higashio, K., Quinn, J. M. W., Gillespie, M. T., Martin, T. J., et al. (2001) · Endocrinology · doi:10.1210/endo.142.8.8300 · Cited by 250
Metadata
- Authors
- Miyazaki, T., Katagiri, H., Kanegae, Y., Takayanagi, H., Sawada, Y., Yamamoto, A., Pando, M. P., Asano, T., Verma, I. M., Oda, H., Nakamura, K., & Tanaka, S.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2000-01-24
- Volume
- 148
- Issue
- 2
- Pages
- 333-342
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2097592282
- Cited by
- 375
- References
- 54
- FWCI
- 6.65
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Miyazaki, T., Katagiri, H., Kanegae, Y., Takayanagi, H., Sawada, Y., Yamamoto, A., Pando, M. P., Asano, T., Verma, I. M., Oda, H., Nakamura, K., & Tanaka, S. (2000). Reciprocal Role of ERK and Nf-κb Pathways in Survival and Activation of Osteoclasts. The Journal of Cell Biology. https://doi.org/10.1083/jcb.148.2.333
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