The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Requirement for β-Catenin in Anterior-Posterior Axis Formation in Mice
Open accessAbstract
The anterior-posterior axis of the mouse embryo is defined before formation of the primitive streak, and axis specification and subsequent anterior development involves signaling from both embryonic ectoderm and visceral endoderm. Τhe Wnt signaling pathway is essential for various developmental processes, but a role in anterior-posterior axis formation in the mouse has not been previously established. β-Catenin is a central player in the Wnt pathway and in cadherin-mediated cell adhesion. We generated β-catenin–deficient mouse embryos and observed a defect in anterior-posterior axis formation at embryonic day 5.5, as visualized by the absence of Hex and Hesx1 and the mislocation of cerberus-like and Lim1 expression. Subsequently, no mesoderm and head structures are generated. Intercellular adhesion is maintained since plakoglobin substitutes for β-catenin. Our data demonstrate that β-catenin function is essential in anterior-posterior axis formation in the mouse, and experiments with chimeric embryos show that this function is required in the embryonic ectoderm.
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Cites
Functional interaction of β-catenin with the transcription factor LEF-1
Behrens, J., von Kries, J. P., Kühl, M., Bruhn, L., Wedlich, D., Grosschedl, R., & Birchmeier, W. (1996) · Nature · doi:10.1038/382638a0 · Cited by 2,912
Self-citationE-cadherin null mutant embryos fail to form a trophectoderm epithelium.
Larue, L., Ohsugi, M., Hirchenhain, J., & Kemler, R. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.17.8263 · Cited by 930
Requirement for LIml in head-organizer function
Shawlot, W., & Behringer, R. R. (1995) · Nature · doi:10.1038/374425a0 · Cited by 805
Thomas, P. Q., Brown, A., & Beddington, R. S. P. (1998) · Development · doi:10.1242/dev.125.1.85 · Cited by 528
Cited by
Sato, N., Meijer, L., Skaltsounis, L., Greengard, P., & Brivanlou, A. H. (2004) · Nature Medicine · doi:10.1038/nm979 · Cited by 2,109
The many faces and functions of β‐catenin
Valenta, T., Hausmann, G., & Basler, K. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.150 · Cited by 1,598
Wnt signalling and its impact on development and cancer
Klaus, A., & Birchmeier, W. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2389 · Cited by 1,595
Self-citationRegulation of bone mass by Wnt signaling
Krishnan, V. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28551 · Cited by 1,407
Canonical Wnt/β-Catenin Signaling Prevents Osteoblasts from Differentiating into Chondrocytes
Hill, T. P., Später, D., Taketo, M. M., Birchmeier, W., & Hartmann, C. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.02.013 · Cited by 1,084
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Metadata
- Authors
- Huelsken, J., Vogel, R., Brinkmann, V., Erdmann, B., Birchmeier, C., & Birchmeier, W.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2000-02-07
- Volume
- 148
- Issue
- 3
- Pages
- 567-578
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2092125592
- Cited by
- 660
- References
- 4
- FWCI
- 8.11
- Type
- journal article
- Language
- en
- Open access
- green
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- Huelsken, J., Vogel, R., Brinkmann, V., Erdmann, B., Birchmeier, C., & Birchmeier, W. (2000). Requirement for β-Catenin in Anterior-Posterior Axis Formation in Mice. The Journal of Cell Biology. https://doi.org/10.1083/jcb.148.3.567
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