E-cadherin null mutant embryos fail to form a trophectoderm epithelium.
Open accessAbstract
The cell adhesion molecule E-cadherin mediates the compaction process of mouse preimplantation embryos and is important for the maintenance and function of epithelial cell layers. To determine precisely the role of E-cadherin in epithelial biogenesis we monitored the developmental potential of embryos homozygously negative for E-cadherin that were derived from E-cadherin heterozygous transgenic mice. The homozygous negative embryos died around the time of implantation, although they did undergo compaction like their littermate controls, largely due to the presence of residual maternal E-cadherin. At the blastocyst stage, E-cadherin-negative embryos failed to form a trophectodermal epithelium or a blastocyst cavity. These results demonstrate the pivotal role of E-cadherin in one of the most basic morphogenetic events in the development of multicellular organisms, the biogenesis of an epithelium.
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E-cadherin is important for tissue morphogenesis and polarity.
“E-cadherin is important for tissue morphogenesis and polarity (Larue et al, 1994).”
From E‐cadherin is essential for in vivo epidermal barrier function by regulating tight junctions (2005) · cites this paper as Larue et al, 1994
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Research works printed but not linked: 7
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- Authors
- Larue, L., Ohsugi, M., Hirchenhain, J., & Kemler, R.
- Affiliations
- Max Planck Society (DE)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1994-08-16
- Volume
- 91
- Issue
- 17
- Pages
- 8263-8267
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC44586
- OpenAlex
- W2102298903
- Cited by
- 930
- References
- 0
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 18 · 2023: 14 · 2022: 26 · 2021: 22 · 2020: 27 · 2019: 32 · 2018: 20 · 2017: 20 · 2016: 24 · 2015: 32 · 2014: 42 · 2013: 35 · 2012: 37
- FWCI
- 11.66
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- E-cadherin, trophectoderm, embryo implantation, adhesion molecules, mouse embryo development
- MeSH terms
- Animals, Base Sequence, Blastocyst, Ectoderm, Epithelial Cells, Epithelium, Exons, Embryonic and Fetal Development, Genes, Lethal, Genetic Vectors, Mice, Inbred C57BL, Molecular Sequence Data, Mutation, Recombination, Genetic, RNA, Messenger, Trophoblasts, Restriction Mapping, Cadherins, Polymerase Chain Reaction, Mice
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