The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Leydig Cell Loss and Spermatogenic Arrest in Platelet-Derived Growth Factor (Pdgf)-a–Deficient Mice
Open accessAbstract
Platelet-derived growth factor (PDGF)- A–deficient male mice were found to develop progressive reduction of testicular size, Leydig cells loss, and spermatogenic arrest. In normal mice, the PDGF-A and PDGF-Rα expression pattern showed positive cells in the seminiferous epithelium and in interstitial mesenchymal cells, respectively. The testicular defects seen in PDGF-A−/− mice, combined with the normal developmental expression of PDGF-A and PDGF-Rα, indicate that through an epithelial-mesenchymal signaling, the PDGF-A gene is essential for the development of the Leydig cell lineage. These findings suggest that PDGF-A may play a role in the cascade of genes involved in male gonad differentiation. The Leydig cell loss and the spermatogenic impairment in the mutant mice are reminiscent of cases of testicular failure in man.
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Cites
Pericyte Loss and Microaneurysm Formation in PDGF-B-Deficient Mice
Lindahl, P., Johansson, B. R., Levéen, P., & Betsholtz, C. (1997) · Science · doi:10.1126/science.277.5323.242 · Cited by 2,226
Self-citationPDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis
Boström, H., Willetts, K., Pekny, M., Levéen, P., Lindahl, P., Hedstrand, H., Pekna, M., Hellström, M., Gebre-Medhin, S., Schalling, M., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81270-2 · Cited by 864
Self-citationEffects of an Igf1 Gene Null Mutation on Mouse Reproduction
Baker, J., Hardy, M. P., Zhou, J., Bondy, C., Lupu, F., Bellvé, A. R., & Efstratiadis, A. (1996) · Molecular Endocrinology · doi:10.1210/mend.10.7.8813730 · Cited by 674
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Armulik, A., Genové, G., & Betsholtz, C. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.07.001 · Cited by 2,653
Self-citationRoles of PDGF in animal development
Hoch, R. V., & Soriano, P. (2003) · Development · doi:10.1242/dev.00721 · Cited by 585
Relaxin family peptides and their receptors
Bathgate, R. A. D., Halls, M. L., van der Westhuizen, E. T., Callander, G. E., Kocan, M., & Summers, R. J. (2013) · Physiological Reviews · doi:10.1152/physrev.00001.2012 · Cited by 534
Targeted Disruption of Luteinizing Hormone/Human Chorionic Gonadotropin Receptor Gene
Lei, Z. M., Mishra, S., Zou, W., Xu, B., Foltz, M., Li, X., & Rao, C. V. (2001) · Molecular Endocrinology · doi:10.1210/me.15.1.184 · Cited by 447
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Metadata
- Authors
- Gnessi, L., Basciani, S., Mariani, S., Arizzi, M., Spera, G., Wang, C., Bondjers, C., Karlsson, L., & Betsholtz, C.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2000-05-29
- Volume
- 149
- Issue
- 5
- Pages
- 1019-1026
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2072611515
- Cited by
- 244
- References
- 3
- FWCI
- 11.18
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Leydig Cell Loss and Spermatogenic Arrest in Platelet-Derived Growth Factor (Pdgf)-a–Deficient Mice. https://app.cochat.ai/papers/10.1083/jcb.149.5.1019
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- Gnessi, L., Basciani, S., Mariani, S., Arizzi, M., Spera, G., Wang, C., Bondjers, C., Karlsson, L., & Betsholtz, C. (2000). Leydig Cell Loss and Spermatogenic Arrest in Platelet-Derived Growth Factor (Pdgf)-a–Deficient Mice. The Journal of Cell Biology. https://doi.org/10.1083/jcb.149.5.1019
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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