The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Mutations in Synaptojanin Disrupt Synaptic Vesicle Recycling
Open accessAbstract
Synaptojanin is a polyphosphoinositide phosphatase that is found at synapses and binds to proteins implicated in endocytosis. For these reasons, it has been proposed that synaptojanin is involved in the recycling of synaptic vesicles. Here, we demonstrate that the unc-26 gene encodes the Caenorhabditis elegans ortholog of synaptojanin. unc-26 mutants exhibit defects in vesicle trafficking in several tissues, but most defects are found at synaptic termini. Specifically, we observed defects in the budding of synaptic vesicles from the plasma membrane, in the uncoating of vesicles after fission, in the recovery of vesicles from endosomes, and in the tethering of vesicles to the cytoskeleton. Thus, these results confirm studies of the mouse synaptojanin 1 mutants, which exhibit defects in the uncoating of synaptic vesicles (Cremona, O., G. Di Paolo, M.R. Wenk, A. Luthi, W.T. Kim, K. Takei, L. Daniell, Y. Nemoto, S.B. Shears, R.A. Flavell, D.A. McCormick, and P. De Camilli. 1999. Cell. 99:179–188), and further demonstrate that synaptojanin facilitates multiple steps of synaptic vesicle recycling.
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Cites
Raucher, D., Stauffer, T., Chen, W., Shen, K., Guo, S., York, J. D., Sheetz, M. P., & Meyer, T. (2000) · Cell · doi:10.1016/s0092-8674(00)81560-3 · Cited by 675
The structure of the ventral nerve cord of Caenorhabditis elegans
White, J. G., Southgate, E., Thomson, J. N., & Brenner, S. (1976) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1976.0086 · Cited by 616
Cited by
The role of phosphoinositides in membrane transport
Simonsen, A., Wurmser, A. E., Emr, S. D., & Stenmark, H. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00240-4 · Cited by 407
The dephosphins: dephosphorylation by calcineurin triggers synaptic vesicle endocytosis
Cousin, M. A., & Robinson, P. J. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01930-5 · Cited by 330
Gerstbrein, B., Stamatas, G., Kollias, N., & Driscoll, M. (2005) · Aging Cell · doi:10.1111/j.1474-9726.2005.00153.x · Cited by 286
Voronov, S. V., Frere, S. G., Giovedi, S., Pollina, E. A., Borel, C., Zhang, H., Schmidt, C., Akeson, E. C., Wenk, M. R., Cimasoni, L., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803756105 · Cited by 174
Synaptojanin and Endophilin Mediate Neck Formation during Ultrafast Endocytosis
Watanabe, S., Mamer, L. E., Raychaudhuri, S., Luvsanjav, D., Eisen, J., Trimbuch, T., Söhl-Kielczynski, B., Fenske, P., Milosevic, I., Rosenmund, C., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.06.005 · Cited by 131
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Metadata
- Authors
- Harris, T. W., Hartwieg, E., Horvitz, H. R., & Jorgensen, E. M.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2000-08-07
- Volume
- 150
- Issue
- 3
- Pages
- 589-600
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2144420636
- Cited by
- 263
- References
- 2
- FWCI
- 7.26
- Type
- journal article
- Language
- en
- Open access
- green
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