The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Δn89β-Catenin Induces Precocious Development, Differentiation, and Neoplasia in Mammary Gland
Open accessAbstract
To investigate the role of β-catenin in mammary gland development and neoplasia, we expressed a stabilized, transcriptionally active form of β-catenin lacking the NH2-terminal 89 amino acids (ΔN89β-catenin) under the control of the mouse mammary tumor virus long terminal repeat. Our results show that ΔN89β-catenin induces precocious lobuloalveolar development and differentiation in the mammary glands of both male and female mice. Virgin ΔN89β-catenin mammary glands resemble those found in wild-type (wt) pregnant mice and inappropriately express cyclin D1 mRNA. In contrast to wt mammary glands, which resume a virgin appearance after cessation of lactation, transgenic mammary glands involute to a midpregnant status. All transgenic females develop multiple aggressive adenocarcinomas early in life. Surprisingly, the ΔN89β-catenin phenotype differs from those elicited by overexpression of Wnt genes in this gland. In particular, ΔN89β-catenin has no effect on ductal side branching. This suggests that Wnt induction of ductal branching involves additional downstream effectors or modulators.
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Functional interaction of β-catenin with the transcription factor LEF-1
Behrens, J., von Kries, J. P., Kühl, M., Bruhn, L., Wedlich, D., Grosschedl, R., & Birchmeier, W. (1996) · Nature · doi:10.1038/382638a0 · Cited by 2,912
Ishitani, T., Ninomiya-Tsuji, J., Nagai, S.-I., Nishita, M., Meneghini, M., Barker, N., Waterman, M., Bowerman, B., Clevers, H., Shibuya, H., et al. (1999) · Nature · doi:10.1038/21674 · Cited by 621
Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4
Stepanova, L., Leng, X., Parker, S. B., & Harper, J. W. (1996) · Genes & Development · doi:10.1101/gad.10.12.1491 · Cited by 483
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β-Catenin and Tcfs in Mammary Development and Cancer
Hatsell, S., Rowlands, T., Hiremath, M., & Cowin, P. (2003) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/a:1025944723047 · Cited by 209
Self-citationPrimary Cilia Regulate Branching Morphogenesis during Mammary Gland Development
McDermott, K. M., Liu, B. Y., Tlsty, T. D., & Pazour, G. J. (2010) · Current Biology · doi:10.1016/j.cub.2010.02.048 · Cited by 100
Metadata
- Authors
- Imbert, A., Eelkema, R., Jordan, S., Feiner, H., & Cowin, P.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2001-04-30
- Volume
- 153
- Issue
- 3
- Pages
- 555-568
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2054374001
- Cited by
- 199
- References
- 3
- FWCI
- 5.10
- Type
- journal article
- Language
- en
- Open access
- green
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- Imbert, A., Eelkema, R., Jordan, S., Feiner, H., & Cowin, P. (2001). Δn89β-Catenin Induces Precocious Development, Differentiation, and Neoplasia in Mammary Gland. The Journal of Cell Biology. https://doi.org/10.1083/jcb.153.3.555
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