The E-cadherin/catenin complex: an important gatekeeper in breast cancer tumorigenesis and malignant progression
Open accessAbstract
E-cadherin is a cell-cell adhesion protein fulfilling a prominent role in epithelial differentiation. Data from model systems suggest that E-cadherin is a potent invasion/tumor suppressor of breast cancer. Consistent with this role in breast cancer progression, partial or complete loss of E-cadherin expression has been found to correlate with poor prognosis in breast cancer patients. The E-cadherin gene (CDH1) is located on human chromosome 16q22.1, a region frequently affected with loss of heterozygosity in sporadic breast cancer. Invasive lobular breast carcinomas, which are typically completely E-cadherin-negative, often show inactivating mutations in combination with loss of heterozygosity of the wild-type CDH1 allele. Mutations were found at early noninvasive stages, thus associating E-cadherin mutations with loss of cell growth control and defining CDH1 as the tumor suppressor for the lobular breast cancer subtype. Ductal breast cancers in general show heterogeneous loss of E-cadherin expression, associated with epigenetic transcriptional downregulation. It is proposed that the microenvironment at the invasive front is transiently downregulating E-cadherin transcription. This can be associated with induction of nonepithelial cadherins.
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The biallelic loss of the CDH1 gene is strongly correlated with lobular breast cancer and a distinct histologic phenotype and biologic behavior.
“The biallelic loss of cadherin 1 (CDH1) gene (encoding E-cadherin) is strongly correlated with lobular breast cancer and a distinct histologic phenotype and biologic behavior65.”
From A foundation model for clinical-grade computational pathology and rare cancers detection (2024) · cites this paper as [65]
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- Authors
- Berx, G., & Roy, F. V.
- Affiliations
- Vlaams Instituut voor Biotechnologie (BE)
- ORCID
- Berx, Geert
- Venue
- Breast Cancer Research
- Published
- 2001-06-28
- Volume
- 3
- Issue
- 5
- Pages
- 289-93
- ISSN
- 1465-5411 (ISSN-L)
- 1465-542X
- PMC
- PMC138690
- OpenAlex
- W2148885171
- Cited by
- 463
- References
- 56
- Citations by year
- 2026: 10 · 2025: 7 · 2024: 6 · 2023: 17 · 2022: 7 · 2021: 28 · 2020: 12 · 2019: 20 · 2018: 14 · 2017: 17 · 2016: 15 · 2015: 22 · 2014: 24 · 2013: 23 · 2012: 32
- FWCI
- 6.86
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Breast Cancer Research (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Health Sciences › Medicine › Pathology and Forensic Medicine › Breast Lesions and Carcinomas
- Keywords
- E-cadherin, breast cancer, tumor suppressor, CDH1, loss of heterozygosity, invasive lobular carcinoma, ductal carcinoma, cell-cell adhesion, tumor invasion, malignant progression, microenvironment, prognosis
- MeSH terms
- Breast Neoplasms, Female, Fungal Proteins, Humans, Mutation, Antigens, CD, Cadherins, Gene Expression Regulation, Neoplastic
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