The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Proteolytic exposure of a cryptic site within collagen type IV is required for angiogenesis and tumor growth in vivo
Open accessAbstract
Evidence is provided that proteolytic cleavage of collagen type IV results in the exposure of a functionally important cryptic site hidden within its triple helical structure. Exposure of this cryptic site was associated with angiogenic, but not quiescent, blood vessels and was required for angiogenesis in vivo. Exposure of the HUIV26 epitope was associated with a loss of α1β1 integrin binding and the gain of αvβ3 binding. A monoclonal antibody (HUIV26) directed to this site disrupts integrin-dependent endothelial cell interactions and potently inhibits angiogenesis and tumor growth. Together, these studies suggest a novel mechanism by which proteolysis contributes to angiogenesis by exposing hidden regulatory elements within matrix-immobilized collagen type IV.
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Cited by
New functions for the matrix metalloproteinases in cancer progression
Egeblad, M., & Werb, Z. (2002) · Nature Reviews Cancer · doi:10.1038/nrc745 · Cited by 6,108
Matrix metalloproteinases and the regulation of tissue remodelling
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Basement membranes: structure, assembly and role in tumour angiogenesis
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Regulation of matrix biology by matrix metalloproteinases
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Metadata
- Authors
- Xu, J., Rodriguez, D., Petitclerc, E., Kim, J. J., Hangai, M., Yuen, S. M., Davis, G. E., & Brooks, P. C.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2001-09-03
- Volume
- 154
- Issue
- 5
- Pages
- 1069-1080
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2156085478
- Cited by
- 489
- References
- 37
- FWCI
- 10.49
- Type
- journal article
- Language
- en
- Open access
- green
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- Xu, J., Rodriguez, D., Petitclerc, E., Kim, J. J., Hangai, M., Yuen, S. M., Davis, G. E., & Brooks, P. C. (2001). Proteolytic exposure of a cryptic site within collagen type IV is required for angiogenesis and tumor growth in vivo. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200103111
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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