The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Matrix assembly, regulation, and survival functions of laminin and its receptors in embryonic stem cell differentiation
Open accessAbstract
Laminin-1 is essential for early embryonic basement membrane assembly and differentiation. Several steps can be distinguished, i.e., the expression of laminin and companion matrix components, their accumulation on the cell surface and assembly into basement membrane between endoderm and inner cell mass, and the ensuing differentiation of epiblast. In this study, we used differentiating embryoid bodies derived from mouse embryonic stem cells null for γ1-laminin, β1-integrin and α/β-dystroglycan to dissect the contributions of laminin domains and interacting receptors to this process. We found that (a) laminin enables β1-integrin–null embryoid bodies to assemble basement membrane and achieve epiblast with β1-integrin enabling expression of the laminin α1 subunit; (b) basement membrane assembly and differentiation require laminin polymerization in conjunction with cell anchorage, the latter critically dependent upon a heparin-binding locus within LG module-4; (c) dystroglycan is not uniquely required for basement membrane assembly or initial differentiation; (d) dystroglycan and integrin cooperate to sustain survival of the epiblast and regulate laminin expression; and (e) laminin, acting via β1-integrin through LG1–3 and requiring polymerization, can regulate dystroglycan expression.
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Cites
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Form and function: The laminin family of heterotrimers
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Self-citationSignals for death and survival: A two-step mechanism for cavitation in the vertebrate embryo
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Self-citationWilliamson, R. A., Henry, M. D., Daniels, K. J., Hrstka, R. F., Lee, J. C., Sunada, Y., Ibraghimov-Beskrovnaya, O., & Campbell, K. P. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.6.831 · Cited by 541
Extracellular matrix assembly and structure
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Appearance and distribution of collagens and laminin in the early mouse embryo
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A Role for Dystroglycan in Basement Membrane Assembly
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Conditional Ablation of β1 Integrin in Skin
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Cited by
Modeling Tissue Morphogenesis and Cancer in 3D
Yamada, K. M., & Cukierman, E. (2007) · Cell · doi:10.1016/j.cell.2007.08.006 · Cited by 1,751
Basement Membranes: Cell Scaffoldings and Signaling Platforms
Yurchenco, P. D. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a004911 · Cited by 959
Self-citationThe impact of the extracellular matrix on inflammation
Sorokin, L. (2010) · Nature Reviews Immunology · doi:10.1038/nri2852 · Cited by 912
Stem Cell Paracrine Actions and Tissue Regeneration
Baraniak, P. R., & McDevitt, T. C. (2010) · Regenerative Medicine · doi:10.2217/rme.09.74 · Cited by 843
LAMININ FUNCTIONS IN TISSUE MORPHOGENESIS
Miner, J. H., & Yurchenco, P. D. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.094555 · Cited by 757
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Metadata
- Authors
- Li, S., Harrison, D., Carbonetto, S., Fässler, R., Smyth, N., Edgar, D., & Yurchenco, P. D.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2002-06-24
- Volume
- 157
- Issue
- 7
- Pages
- 1279-1290
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2090698927
- Cited by
- 320
- References
- 36
- FWCI
- 11.94
- Type
- journal article
- Language
- en
- Open access
- green
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- Li, S., Harrison, D., Carbonetto, S., Fässler, R., Smyth, N., Edgar, D., & Yurchenco, P. D. (2002). Matrix assembly, regulation, and survival functions of laminin and its receptors in embryonic stem cell differentiation. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200203073
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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