Modeling Tissue Morphogenesis and Cancer in 3D
Open accessAbstract
Three-dimensional (3D) in vitro models span the gap between two-dimensional cell cultures and whole-animal systems. By mimicking features of the in vivo environment and taking advantage of the same tools used to study cells in traditional cell culture, 3D models provide unique perspectives on the behavior of stem cells, developing tissues and organs, and tumors. These models may help to accelerate translational research in cancer biology and tissue engineering.
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Various tumor spheroids have been fabricated by embedding cancer cells into protein-based hydrogels such as Matrigel, fibrin, and collagen as they incorporate specific cell-adhesive motifs and enzymatic-mediated matrix degradation beneficial to cell proliferation.
“Currently, various tumor spheroids have been fabricated by embedding cancer cells into protein‐based hydrogels such as Matrigel,[ 64 ] fibrin,[ 65 ] and collagen[ 66 ] as they incorporate specific cell‐adhesive motifs and enzymatic‐mediated matrix degradation which are beneficial to cell proliferation.”
From 3D Biomimetic Models to Reconstitute Tumor Microenvironment In Vitro: Spheroids, Organoids, and Tumor‐on‐a‐Chip (2023) · cites this paper as [64]
The mechanical properties of BME cannot be tailored, rendering it unable to study mechanotransduction during organogenesis.
“the mechanical properties of BME cannot be tailored, rendering it unable to study mechanotransduction during organogenesis.”
From 3D Biomimetic Models to Reconstitute Tumor Microenvironment In Vitro: Spheroids, Organoids, and Tumor‐on‐a‐Chip (2023) · cites this paper as [64]
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- Authors
- Yamada, K. M., & Cukierman, E.
- Affiliations
- National Institutes of Health (US)
- Fox Chase Cancer Center (US)
- Corresponding author
- Yamada, Kenneth M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2007-08
- Volume
- 130
- Issue
- 4
- Pages
- 601-610
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2010251891
- Cited by
- 1,751
- References
- 10
- Citations by year
- 2026: 31 · 2025: 53 · 2024: 61 · 2023: 73 · 2022: 74 · 2021: 92 · 2020: 119 · 2019: 120 · 2018: 126 · 2017: 118 · 2016: 133 · 2015: 115 · 2014: 130 · 2013: 121 · 2012: 101
- FWCI
- 4.91
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (R21CA109442)
- National Institute of Dental and Craniofacial Research
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- 3D in vitro model, tissue morphogenesis, cancer, stem cells, organogenesis, tumor modeling, tissue engineering, tumor biology
- MeSH terms
- Humans, Models, Biological, Morphogenesis, Neoplasms, Organ Culture Techniques, Tumor Cells, Cultured, Cell Culture Techniques, Imaging, Three-Dimensional
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