The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
p120 catenin associates with kinesin and facilitates the transport of cadherin–catenin complexes to intercellular junctions
Open accessAbstract
p120 catenin (p120) is a component of adherens junctions and has been implicated in regulating cadherin-based cell adhesion as well as the activity of Rho small GTPases, but its exact roles in cell–cell adhesion are unclear. Using time-lapse imaging, we show that p120-GFP associates with vesicles and exhibits unidirectional movements along microtubules. Furthermore, p120 forms a complex with kinesin heavy chain through the p120 NH2-terminal head domain. Overexpression of p120, but not an NH2-terminal deletion mutant deficient in kinesin binding, recruits endogenous kinesin to N-cadherin. Disruption of the interaction between N-cadherin and p120, or the interaction between p120 and kinesin, leads to a delayed accumulation of N-cadherin at cell–cell contacts during calcium-initiated junction reassembly. Our analyses identify a novel role of p120 in promoting cell surface trafficking of cadherins via association and recruitment of kinesin.
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Citations
Cites
Light Chain– dependent Regulation of Kinesin's Interaction with Microtubules
Verhey, K. J., Lizotte, D. L., Abramson, T., Barenboim, L., Schnapp, B. J., & Rapoport, T. A. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.4.1053 · Cited by 266 · cited 6×
“Immunoblots were performed using antibodies as follows: p120 mouse monoclonal antibody used at 1:1,000; anti-p120 rabbit polyclonal antibody F1-SH used at 1:3,440; mouse anti-KHC antibody (H2; CHEMICON International) used at 1:1,000; rabbit anti-KHC peptide antibody KHC13 used at 1:2,500 (a gift from Dr. Kristen J. Ve…”
BackgroundMethodInfluential
Cited by
Adherens junctions: from molecules to morphogenesis
Harris, T. J. C., & Tepass, U. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2927 · Cited by 990
Niessen, C. M., Leckband, D., & Yap, A. S. (2011) · Physiological Reviews · doi:10.1152/physrev.00004.2010 · Cited by 427
Rab11 in Recycling Endosomes Regulates the Sorting and Basolateral Transport of E-Cadherin
Lock, J. G., & Stow, J. L. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-10-0867 · Cited by 389
Working out the strength and flexibility of desmosomes
Getsios, S., Huen, A. C., & Green, K. J. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1356 · Cited by 342
Self-citationReelin, Rap1 and N-cadherin orient the migration of multipolar neurons in the developing neocortex
Jossin, Y., & Cooper, J. A. (2011) · Nature Neuroscience · doi:10.1038/nn.2816 · Cited by 332
Metadata
- Authors
- Chen, X., Kojima, S.-I., Borisy, G. G., & Green, K. J.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2003-11-10
- Volume
- 163
- Issue
- 3
- Pages
- 547-557
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W14610057
- Cited by
- 259
- References
- 1
- FWCI
- 11.48
- Type
- journal article
- Language
- en
- Open access
- green
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- Chen, X., Kojima, S.-I., Borisy, G. G., & Green, K. J. (2003). p120 catenin associates with kinesin and facilitates the transport of cadherin–catenin complexes to intercellular junctions. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200305137
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