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Cited by 389

The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.

Rab11 in Recycling Endosomes Regulates the Sorting and Basolateral Transport of E-Cadherin

Open access
Lock, John G., Stow, Jennifer L.·2005·Molecular Biology of the Cell
DOI 10.1091/mbc.e04-10-0867
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Abstract

E-cadherin plays an essential role in cell polarity and cell-cell adhesion; however, the pathway for delivery of E-cadherin to the basolateral membrane of epithelial cells has not been fully characterized. We first traced the post-Golgi, exocytic transport of GFP-tagged E-cadherin (Ecad-GFP) in unpolarized cells. In live cells, Ecad-GFP was found to exit the Golgi complex in pleiomorphic tubulovesicular carriers, which, instead of moving directly to the cell surface, most frequently fused with an intermediate compartment, subsequently identified as a Rab11-positive recycling endosome. In MDCK cells, basolateral targeting of E-cadherin relies on a dileucine motif. Both E-cadherin and a targeting mutant, ΔS1-E-cadherin, colocalized with Rab11 and fused with the recycling endosome before diverging to basolateral or apical membranes, respectively. In polarized and unpolarized cells, coexpression of Rab11 mutants disrupted the cell surface delivery of E-cadherin and caused its mistargeting to the apical membrane, whereas apical ΔS1-E-cadherin was unaffected. We thus demonstrate a novel pathway for Rab11 dependent, dileucine-mediated, μ1B-independent sorting and basolateral trafficking, exemplified by E-cadherin. The recycling endosome is identified as an intermediate compartment for the post-Golgi trafficking and exocytosis of E-cadherin, with a potentially important role in establishing and maintaining cadherin-based adhesion.

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Metadata

Authors
Lock, J. G., & Stow, J. L.
Venue
Molecular Biology of the Cell
Publisher
American Society for Cell Biology (ASCB)
Published
2005-04
Volume
16
Issue
4
Pages
1744-1755
ISSN
  • 1059-1524 (ISSN-L)
  • 1939-4586
DOI
10.1091/mbc.e04-10-0867
OpenAlex
W2162669567
Cited by
389
References
53
FWCI
10.76
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Rab11 in Recycling Endosomes Regulates the Sorting and Basolateral Transport of E-Cadherin. https://app.cochat.ai/papers/10.1091/mbc.e04-10-0867
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Lock, J. G., & Stow, J. L. (2005). Rab11 in Recycling Endosomes Regulates the Sorting and Basolateral Transport of E-Cadherin. Molecular Biology of the Cell. https://doi.org/10.1091/mbc.e04-10-0867

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