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A core function for p120-catenin in cadherin turnover
Open accessAbstract
p120-catenin stabilizes epithelial cadherin (E-cadherin) in SW48 cells, but the mechanism has not been established. Here, we show that p120 acts at the cell surface to control cadherin turnover, thereby regulating cadherin levels. p120 knockdown by siRNA expression resulted in dose-dependent elimination of epithelial, placental, neuronal, and vascular endothelial cadherins, and complete loss of cell–cell adhesion. ARVCF and δ-catenin were functionally redundant, suggesting that proper cadherin-dependent adhesion requires the presence of at least one p120 family member. The data reveal a core function of p120 in cadherin complexes, and strongly predict a dose-dependent loss of E-cadherin in tumors that partially or completely down-regulate p120.
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Polakis, P. (2000) · Genes & Development · doi:10.1101/gad.14.15.1837 · Cited by 3,183
Vleminckx, K., Vakaet, L., Mareel, M., Fiers, W., & Van Roy, F. (1991) · Cell · doi:10.1016/0092-8674(91)90143-m · Cited by 1,656
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Metadata
- Authors
- Davis, M. A., Ireton, R. C., & Reynolds, A. B.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2003-11-10
- Volume
- 163
- Issue
- 3
- Pages
- 525-534
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2085179400
- Cited by
- 732
- References
- 2
- FWCI
- 19.35
- Type
- journal article
- Language
- en
- Open access
- green
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- Davis, M. A., Ireton, R. C., & Reynolds, A. B. (2003). A core function for p120-catenin in cadherin turnover. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200307111
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
