Cited by 152Mitochondrial Function and PathologyAutophagy in Disease and TherapyFungal and yeast genetics research

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Mmm2p, a mitochondrial outer membrane protein required for yeast mitochondrial shape and maintenance of mtDNA nucleoids

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Youngman, Matthew J., Hobbs, Alyson E. Aiken, Burgess, Shawn M., Srinivasan, Maithreyan, Jensen, Robert E.·2004·The Journal of Cell Biology

DOI 10.1083/jcb.200308012PMC PMC2172170

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Abstract

The mitochondrial outer membrane protein, Mmm1p, is required for normal mitochondrial shape in yeast. To identify new morphology proteins, we isolated mutations incompatible with the mmm1-1 mutant. One of these mutants, mmm2-1, is defective in a novel outer membrane protein. Lack of Mmm2p causes a defect in mitochondrial shape and loss of mitochondrial DNA (mtDNA) nucleoids. Like the Mmm1 protein (Aiken Hobbs, A.E., M. Srinivasan, J.M. McCaffery, and R.E. Jensen. 2001. J. Cell Biol. 152:401-410.), Mmm2p is located in dot-like particles on the mitochondrial surface, many of which are adjacent to mtDNA nucleoids. While some of the Mmm2p-containing spots colocalize with those containing Mmm1p, at least some of Mmm2p is separate from Mmm1p. Moreover, while Mmm2p and Mmm1p both appear to be part of large complexes, we find that Mmm2p and Mmm1p do not stably interact and appear to be members of two different structures. We speculate that Mmm2p and Mmm1p are components of independent machinery, whose dynamic interactions are required to maintain mitochondrial shape and mtDNA structure.

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Additional file 1 of The divergent ER-mitochondria encounter structures (ERMES) are conserved in parabasalids but lost in several anaerobic lineages with hydrogenosomes
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Additional file 2 of The divergent ER-mitochondria encounter structures (ERMES) are conserved in parabasalids but lost in several anaerobic lineages with hydrogenosomes
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Additional file 3 of The divergent ER-mitochondria encounter structures (ERMES) are conserved in parabasalids but lost in several anaerobic lineages with hydrogenosomes
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Additional file 5 of The divergent ER-mitochondria encounter structures (ERMES) are conserved in parabasalids but lost in several anaerobic lineages with hydrogenosomes
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Additional file 7 of The divergent ER-mitochondria encounter structures (ERMES) are conserved in parabasalids but lost in several anaerobic lineages with hydrogenosomes
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Additional file 6 of The divergent ER-mitochondria encounter structures (ERMES) are conserved in parabasalids but lost in several anaerobic lineages with hydrogenosomes
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Additional file 4 of The divergent ER-mitochondria encounter structures (ERMES) are conserved in parabasalids but lost in several anaerobic lineages with hydrogenosomes
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Authors: Youngman, M. J., Hobbs, A. E. A., Burgess, S. M., Srinivasan, M., & Jensen, R. E.
Affiliations: Johns Hopkins University (US)
ORCID: Youngman, Matthew J.
Burgess, Shawn M.
Srinivasan, Maithreyan
Jensen, Robert E.
Venue: The Journal of Cell Biology
Publisher: Rockefeller University Press
Published: 2004-02-23
Volume: 164
Issue: 5
Pages: 677-688
ISSN: 0021-9525 (ISSN-L)
1540-8140
DOI: 10.1083/jcb.200308012
PMC: PMC2172170
OpenAlex: W1964155535
Cited by: 148
References: 53
Citations by year: 2026: 1 · 2025: 3 · 2024: 5 · 2023: 4 · 2022: 3 · 2021: 5 · 2020: 6 · 2019: 3 · 2018: 8 · 2017: 8 · 2016: 12 · 2015: 4 · 2014: 15 · 2013: 7 · 2012: 5
FWCI: 2.96
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: cc-by-nc-sa
Locations: The Journal of Cell Biology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (R01GM054021, T32GM007445, R01-GM54021, 2T32-GM07445)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords: mitochondrial outer membrane proteins, mitochondrial morphology, mtDNA maintenance, Saccharomyces cerevisiae, protein-protein interaction, protein complex structure
MeSH terms: Cell Division, Cell Membrane, DNA, Mitochondrial, Membrane Proteins, Mitochondria, Nucleic Acid Conformation, Recombinant Fusion Proteins, Saccharomyces cerevisiae, Subcellular Fractions, Mitochondrial Proteins, Saccharomyces cerevisiae Proteins, Macromolecular Substances

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Mmm2p, a mitochondrial outer membrane protein required for yeast mitochondrial shape and maintenance of mtDNA nucleoids

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