The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Human telomerase RNA and box H/ACA scaRNAs share a common Cajal body–specific localization signal
Open accessAbstract
Telomerase is a ribonucleoprotein reverse transcriptase that uses its RNA component as a template for synthesis of telomeric DNA repeats at the ends of linear eukaryotic chromosomes. Here, fluorescence in situ hybridization demonstrates that in HeLa cancer cells, human telomerase RNA (hTR) accumulates in the nucleoplasmic Cajal bodies (CBs). Localization of transiently expressed hTR to CBs is supported by a short sequence motif (411-UGAG-414) that is located in the 3′-terminal box H/ACA RNA-like domain of hTR and that is structurally and functionally indistinguishable from the CB-specific localization signal of box H/ACA small CB-specific RNAs. In synchronized HeLa cells, hTR shows the most efficient accumulation in CBs during S phase, when telomeres are most likely synthesized. CBs may function in post-transcriptional maturation (e.g., cap hypermethylation of hTR), but they may also play a role in the assembly and/or function of telomerase holoenzyme.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The RNA Component of Human Telomerase
Feng, J., Funk, W. D., Wang, S.-S., Weinrich, S. L., Avilion, A. A., Chiu, C.-P., Adams, R. R., Chang, E., Allsopp, R. C., Yu, J., et al. (1995) · Science · doi:10.1126/science.7544491 · Cited by 2,227
Protection of mammalian telomeres
de Lange, T. (2002) · Oncogene · doi:10.1038/sj.onc.1205080 · Cited by 942
A novel nuclear structure containing the survival of motor neurons protein.
Liu, Q., & Dreyfuss, G. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00725.x · Cited by 780
McEachern, M. J., Krauskopf, A., & Blackburn, E. H. (2000) · Annual Review of Genetics · doi:10.1146/annurev.genet.34.1.331 · Cited by 716
The SMN–SIP1 Complex Has an Essential Role in Spliceosomal snRNP Biogenesis
Fischer, U., Liu, Q., & Dreyfuss, G. (1997) · Cell · doi:10.1016/s0092-8674(00)80368-2 · Cited by 658
Secondary Structure of Vertebrate Telomerase RNA
Chen, J.-L., Blasco, M. A., & Greider, C. W. (2000) · Cell · doi:10.1016/s0092-8674(00)80687-x · Cited by 605
Telomerase in the human organism
Collins, K., & Mitchell, J. R. (2002) · Oncogene · doi:10.1038/sj.onc.1205083 · Cited by 603
Essential Role for the SMN Complex in the Specificity of snRNP Assembly
Pellizzoni, L., Yong, J., & Dreyfuss, G. (2002) · Science · doi:10.1126/science.1074962 · Cited by 545
Crissman, H. A., & Steinkamp, J. A. (1973) · The Journal of Cell Biology · doi:10.1083/jcb.59.3.766 · Cited by 544
A Box H/ACA Small Nucleolar RNA-Like Domain at the Human Telomerase RNA 3′ End
Mitchell, J. R., Cheng, J., & Collins, K. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.1.567 · Cited by 510
Cited by
Morris, K. V., & Mattick, J. S. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3722 · Cited by 1,371
Non-coding RNAs: lessons from the small nuclear and small nucleolar RNAs
Matera, A. G., Terns, R. M., & Terns, M. P. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2124 · Cited by 877
Telomeres and telomerase in cancer
Artandi, S. E., & DePinho, R. A. (2010) · Carcinogenesis · doi:10.1093/carcin/bgp268 · Cited by 823
A Human Telomerase Holoenzyme Protein Required for Cajal Body Localization and Telomere Synthesis
Venteicher, A. S., Abreu, E. B., Meng, Z., McCann, K. E., Terns, R. M., Veenstra, T. D., Terns, M. P., & Artandi, S. E. (2009) · Science · doi:10.1126/science.1165357 · Cited by 522
The structure and function of small nucleolar ribonucleoproteins
Reichow, S. L., Hamma, T., Ferre-D'Amare, A. R., & Varani, G. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkl1172 · Cited by 413
Metadata
- Authors
- Jády, B. E., Bertrand, E., & Kiss, T.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2004-02-23
- Volume
- 164
- Issue
- 5
- Pages
- 647-652
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W1991934695
- Cited by
- 274
- References
- 33
- FWCI
- 9.12
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Human telomerase RNA and box H/ACA scaRNAs share a common Cajal body–specific localization signal. https://app.cochat.ai/papers/10.1083/jcb.200310138
- The paper
- Jády, B. E., Bertrand, E., & Kiss, T. (2004). Human telomerase RNA and box H/ACA scaRNAs share a common Cajal body–specific localization signal. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200310138
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
