A Human Telomerase Holoenzyme Protein Required for Cajal Body Localization and Telomere Synthesis

A telomerase component is defective in the human disease dyskeratosis congenita

Mitchell, J. R., Wood, E., & Collins, K. (1999) · Nature · doi:10.1038/990141 · Cited by 1,168 · see citing works

Non-coding RNAs: lessons from the small nuclear and small nucleolar RNAs

Matera, A. G., Terns, R. M., & Terns, M. P. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2124 · Cited by 831 · see citing works

The POT1-TPP1 telomere complex is a telomerase processivity factor.

Wang, F., Podell, E. R., Zaug, A. J., Yang, Y., Baciu, P., Cech, T. R., & Lei, M. (2007) · Nature · doi:10.1038/nature05454 · Cited by 704 · see citing works

Protein Composition of Catalytically Active Human Telomerase from Immortal Cells

Cohen, S. B., Graham, M. E., Lovrecz, G. O., Bache, N., Robinson, P. J., & Reddel, R. R. (2007) · Science · doi:10.1126/science.1138596 · Cited by 669 · see citing works

TPP1 is a homologue of ciliate TEBP-β and interacts with POT1 to recruit telomerase

Xin, H., Liu, D., Wan, M., Safari, A., Kim, H., Sun, W., O’Connor, M. S., & Songyang, Z. (2007) · Nature · doi:10.1038/nature05469 · Cited by 486 · see citing works

Identification of ATPases Pontin and Reptin as Telomerase Components Essential for Holoenzyme Assembly

Venteicher, A. S., Meng, Z., Mason, P. J., Veenstra, T. D., & Artandi, S. E. (2008) · Cell · doi:10.1016/j.cell.2008.01.019 · Cited by 329 · see citing works

Cell Cycle-regulated Trafficking of Human Telomerase to Telomeres

Tomlinson, R. L., Ziegler, T. D., Supakorndej, T., Terns, R. M., & Terns, M. P. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-09-0903 · Cited by 326 · see citing works

The biogenesis and regulation of telomerase holoenzymes

Collins, K. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1961 · Cited by 282 · see citing works

Human telomerase RNA and box H/ACA scaRNAs share a common Cajal body–specific localization signal

Jády, B. E., Bertrand, É., & Kiss, T. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200310138 · Cited by 272 · see citing works

The many facets of H/ACA ribonucleoproteins

Meier, U. T. (2005) · Chromosoma · doi:10.1007/s00412-005-0333-9 · Cited by 269 · see citing works

NAP57, a mammalian nucleolar protein with a putative homolog in yeast and bacteria.

Meier, U. T., & Blobel, G. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.127.6.1505 · Cited by 258 · see citing works

Dyskeratosis congenita: a genetic disorder of many faces

Kirwan, M., & Dokal, I. S. (2007) · Clinical Genetics · doi:10.1111/j.1399-0004.2007.00923.x · Cited by 238 · see citing works

Purification of Human Telomerase Complexes Identifies Factors Involved in Telomerase Biogenesis and Telomere Length Regulation

Fu, D., & Collins, K. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.09.023 · Cited by 229 · see citing works

Human H/ACA Small Nucleolar RNPs and Telomerase Share Evolutionarily Conserved Proteins NHP2 and NOP10

Pogačić, V., Dragon, F., & Filipowicz, W. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.23.9028-9040.2000 · Cited by 224 · see citing works

Cell Cycle-dependent Recruitment of Telomerase RNA and Cajal Bodies to Human Telomeres

Jády, B. E., Richard, P., Bertrand, É., & Kiss, T. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-09-0904 · Cited by 204 · see citing works

A Human Homolog of Yeast Est1 Associates with Telomerase and Uncaps Chromosome Ends When Overexpressed

Reichenbach, P., Höss, M., Azzalin, C. M., Nabholz, M., Bücher, P., & Lingner, J. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00173-8 · Cited by 198 · see citing works

Telomerase RNA Accumulates in Cajal Bodies in Human Cancer Cells

Zhu, Y., Tomlinson, R. L., Lukowiak, A. A., Terns, R. M., & Terns, M. P. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-07-0525 · Cited by 193 · see citing works

Mouse dyskerin mutations affect accumulation of telomerase RNA and small nucleolar RNA, telomerase activity, and ribosomal RNA processing

Mochizuki, Y., He, J. L., Kulkarni, S., Bessler, M., & Mason, P. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402560101 · Cited by 188 · see citing works

Human Telomerase RNA Accumulation in Cajal Bodies Facilitates Telomerase Recruitment to Telomeres and Telomere Elongation

Cristofari, G., Adolf, E., Reichenbach, P., Sikora, K. O., Terns, R. M., Terns, M. P., & Lingner, J. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.07.020 · Cited by 185 · see citing works

Functional Conservation of the Telomerase Protein Est1p in Humans

Snow, B. E., Erdmann, N., Cruickshank, J., Goldman, H., Gill, R. M., Robinson, M. O., & Harrington, L. A. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00210-0 · Cited by 170 · see citing works

In Vitro Assembly of Human H/ACA Small Nucleolar RNPs Reveals Unique Features of U17 and Telomerase RNAs

Dragon, F., Pogačić, V., & Filipowicz, W. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.9.3037-3048.2000 · Cited by 166 · see citing works

One-step affinity purification protocol for human telomerase

Schnapp, G. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.13.3311 · Cited by 101 · see citing works

hNaf1 is required for accumulation of human box H/ACA snoRNPs, scaRNPs, and telomerase

Hoareau‐Aveilla, C., Bonoli, M., Caizergues‐Ferrer, M., & Henry, Y. A. L. (2006) · RNA · doi:10.1261/rna.2344106 · Cited by 59 · see citing works

The Noncoding RNA Revolution—Trashing Old Rules to Forge New Ones

Cech, T. R., & STEITZ, J. A. (2014) · Cell · doi:10.1016/j.cell.2014.03.008 · Cited by 2,456 · see citing works

Genomic Maps of Long Noncoding RNA Occupancy Reveal Principles of RNA-Chromatin Interactions

Chu, C., Qu, K., Zhong, F. L., Artandi, S. E., & Chang, H. Y. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.08.027 · Cited by 1,274 · see citing works

Telomeres: protecting chromosomes against genome instability

O’Sullivan, R. J., & Karlseder, J. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2848 · Cited by 994 · see citing works

The telomere syndromes

Armanios, M., & Blackburn, E. H. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3246 · Cited by 982 · see citing works

Telomeres and telomerase in cancer

Artandi, S. E., & DePinho, R. A. (2010) · Carcinogenesis · doi:10.1093/carcin/bgp268 · Cited by 823 · see citing works

Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies

Jafri, M. A., Ansari, S. A., Alqahtani, M. H., & Shay, J. W. (2016) · Genome Medicine · doi:10.1186/s13073-016-0324-x · Cited by 716 · see citing works

An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA

Maida, Y., Yasukawa, M., Furuuchi, M., Lassmann, T., Possemato, R., Okamoto, N., Kasim, V., Hayashizaki, Y., Hahn, W. C., & Masutomi, K. (2009) · Nature · doi:10.1038/nature08283 · Cited by 384 · see citing works

Finding the end: recruitment of telomerase to telomeres

Nandakumar, J., & Cech, T. R. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3505 · Cited by 378 · see citing works

Regulation of human telomerase in homeostasis and disease

Roake, C. M., & Artandi, S. E. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0234-z · Cited by 341 · see citing works

Telomerase: An RNP Enzyme Synthesizes DNAPreprint

Blackburn, E. H., & Collins, K. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003558 · Cited by 333 · see citing works

Telomeres and Telomere Length: A General Overview

Srinivas, N., Rachakonda, P. S., & Kumar, R. (2020) · Cancers · doi:10.3390/cancers12030558 · Cited by 313 · see citing works

Human telomerase: biogenesis, trafficking, recruitment, and activationPreprint

Schmidt, J. C., & Cech, T. R. (2015) · Genes & Development · doi:10.1101/gad.263863.115 · Cited by 301 · see citing works

Diverse role of survival motor neuron protein

Singh, R. N., Howell, M. D., Ottesen, E. W., & Singh, N. N. (2017) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2016.12.008 · Cited by 301 · see citing works

TPP1 OB-Fold Domain Controls Telomere Maintenance by Recruiting Telomerase to Chromosome Ends

Zhong, F. L., Batista, L. F. Z., Freund, A., Pech, M. F., Venteicher, A. S., & Artandi, S. E. (2012) · Cell · doi:10.1016/j.cell.2012.07.012 · Cited by 295 · see citing works

RNA pseudouridylation: new insights into an old modification

Ge, J., & Yu, Y. (2013) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2013.01.002 · Cited by 276 · see citing works

The Cajal Body and Histone Locus BodyPreprint

Nizami, Z. F., Deryusheva, S., & Gall, J. G. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000653 · Cited by 276 · see citing works

Box H/ACA Small Ribonucleoproteins

Kiss, T., Fayet-Lebaron, E., & Jády, B. E. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.01.032 · Cited by 267 · see citing works

Disruption of telomerase trafficking by TCAB1 mutation causes dyskeratosis congenita

Zhong, F., Savage, S. A., Shkreli, M., Giri, N., Jessop, L., Myers, T., Chen, R., Alter, B. P., & Artandi, S. E. (2011) · Genes & Development · doi:10.1101/gad.2006411 · Cited by 262 · see citing works

Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells

Batista, L. F. Z., Pech, M. F., Zhong, F. L., Nguyen, H. N., Xie, K. T., Zaug, A. J., Crary, S. M., Choi, J., Sebastiano, V., Cherry, A. M., et al. (2011) · Nature · doi:10.1038/nature10084 · Cited by 260 · see citing works

The genetics and clinical manifestations of telomere biology disorders

Savage, S. A., & Bertuch, A. A. (2010) · Genetics in Medicine · doi:10.1097/gim.0b013e3181f415b5 · Cited by 257 · see citing works

Targeting telomerase for cancer therapy

Guterres, A. N., & Villanueva, J. (2020) · Oncogene · doi:10.1038/s41388-020-01405-w · Cited by 256 · see citing works

TIN2-Tethered TPP1 Recruits Human Telomerase to Telomeres In Vivo

Abreu, E. B., Aritonovska, E., Reichenbach, P., Cristofari, G., Culp, B. R., Terns, R. M., Lingner, J., & Terns, M. P. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00240-10 · Cited by 240 · see citing works

TERT promoter mutations in cancer development

Heidenreich, B., Rachakonda, P. S., Hemminki, K., & Kumar, R. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2013.11.005 · Cited by 238 · see citing works

Genetics of human telomere biology disorders

Revy, P., Kannengiesser, C., & Bertuch, A. A. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00527-z · Cited by 242 · see citing works

Cryo-EM structure of substrate-bound human telomerase holoenzyme

Nguyen, T. H. D., Tam, J., Wu, R. A., Greber, B. J., Toso, D. B., Nogales, E., & Collins, K. (2018) · Nature · doi:10.1038/s41586-018-0062-x · Cited by 231 · see citing works

Structural biology of telomeres and telomerase

Smith, E. M., Pendlebury, D. F., & Nandakumar, J. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03369-x · Cited by 228 · see citing works

Telomerase Mechanism of Telomere Synthesis

Wu, R. A., Upton, H. E., Vogan, J. M., & Collins, K. (2017) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-061516-045019 · Cited by 208 · see citing works

A Conserved WD40 Protein Binds the Cajal Body Localization Signal of scaRNP Particles

Tycowski, K. T., Shu, M.-D., Kukoyi, A., & Steitz, J. A. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.02.020 · Cited by 212 · see citing works

Maintaining the end: Roles of telomere proteins in end-protection, telomere replication and length regulation

Stewart, J. A., Fedor‐Chaiken, M., Wang, F., & Price, C. M. (2011) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2011.08.011 · Cited by 208 · see citing works

Updates on the biology and management of dyskeratosis congenita and related telomere biology disorders

Ballew, B. J., & Savage, S. A. (2013) · Expert Review of Hematology · doi:10.1586/ehm.13.23 · Cited by 212 · see citing works

Structure of human telomerase holoenzyme with bound telomeric DNA

Ghanim, G. E., Fountain, A. J., van Roon, A. M., Rangan, R., Das, R., Collins, K., & Nguyen, T. H. D. (2021) · Nature · doi:10.1038/s41586-021-03415-4 · Cited by 201 · see citing works

Assembly and trafficking of box C/D and H/ACA snoRNPs

Massenet, S., Bertrand, É., & Verheggen, C. (2016) · RNA Biology · doi:10.1080/15476286.2016.1243646 · Cited by 200 · see citing works

TERT promoter mutations in telomere biology

Heidenreich, B., & Kumar, R. (2016) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2016.11.002 · Cited by 198 · see citing works

Yeast telomerase and the SUN domain protein Mps3 anchor telomeres and repress subtelomeric recombinationPreprint

Schober, H., Ferreira, H. C., Kalck, V., Gehlen, L. R., & Gasser, S. M. (2009) · Genes & Development · doi:10.1101/gad.1787509 · Cited by 189 · see citing works

Nuclear Bodies: Random Aggregates of Sticky Proteins or Crucibles of Macromolecular Assembly?

Matera, A. G., Izaguire-Sierra, M., Praveen, K., & Rajendra, T. K. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.10.017 · Cited by 186 · see citing works

Live Cell Imaging Reveals the Dynamics of Telomerase Recruitment to Telomeres

Schmidt, J. C., Zaug, A. J., & Cech, T. R. (2016) · Cell · doi:10.1016/j.cell.2016.07.033 · Cited by 177 · see citing works

Cajal bodies: where form meets function

Machyna, M., Heyn, P. C., & Neugebauer, K. M. (2012) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1139 · Cited by 185 · see citing works

InTERTpreting telomerase structure and function

Wyatt, H. D. M., West, S. C., & Beattie, T. L. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq370 · Cited by 183 · see citing works

Poly(A)-specific ribonuclease (PARN) mediates 3′-end maturation of the telomerase RNA component

Moon, D. H., Segal, M., Boyraz, B., Guinan, E. C., Hofmann, I., Cahan, P., Tai, A., & Agarwal, S. (2015) · Nature Genetics · doi:10.1038/ng.3423 · Cited by 183 · see citing works

Telomerase gene mutations are associated with cirrhosis formation

Hartmann, D., Srivastava, U., Thaler, M., Kleinhans, K. N., N'Kontchou, G., Scheffold, A., Bauer, K., Kratzer, R. F., Kloos, N., Katz, S.-F., et al. (2011) · Hepatology · doi:10.1002/hep.24217 · Cited by 173 · see citing works

Biogenesis of telomerase ribonucleoproteins

Egan, E. D., & Collins, K. (2012) · RNA · doi:10.1261/rna.034629.112 · Cited by 177 · see citing works

An update on the biology and management of dyskeratosis congenita and related telomere biology disorders

Niewisch, M. R., & Savage, S. A. (2019) · Expert Review of Hematology · doi:10.1080/17474086.2019.1662720 · Cited by 179 · see citing works

Nuclear bodies: multifunctional companions of the genome

Dundr, M. (2012) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2012.03.010 · Cited by 169 · see citing works

The molecular genetics of the telomere biology disorders

Bertuch, A. A. (2015) · RNA Biology · doi:10.1080/15476286.2015.1094596 · Cited by 169 · see citing works

A pathophysiological view of the long non-coding RNA world

Gesualdo, F. D., Capaccioli, S., & Lulli, M. (2014) · Oncotarget · doi:10.18632/oncotarget.2770 · Cited by 166 · see citing works

Cajal bodies are linked to genome conformation

Wang, Q., Sawyer, I. A., Sung, M.-H., Sturgill, D., Shevtsov, S. P., Pegoraro, G., Hakim, O., Baek, S., Hager, G. L., & Dundr, M. (2016) · Nature Communications · doi:10.1038/ncomms10966 · Cited by 164 · see citing works

Healthy aging and disease: role for telomere biology?

Zhu, H., Belcher, M. D., & van der Harst, P. (2011) · Clinical Science · doi:10.1042/cs20100385 · Cited by 163 · see citing works

The genetics of dyskeratosis congenita

Mason, P. J., & Bessler, M. (2011) · Cancer Genetics · doi:10.1016/j.cancergen.2011.11.002 · Cited by 159 · see citing works

Architecture of human telomerase RNA

Zhang, Q., Kim, N.-K., & Feigon, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100279108 · Cited by 157 · see citing works

Proteostatic Control of Telomerase Function through TRiC-Mediated Folding of TCAB1

Freund, A., Zhong, F. L., Venteicher, A. S., Meng, Z., Veenstra, T. D., Frydman, J., & Artandi, S. E. (2014) · Cell · doi:10.1016/j.cell.2014.10.059 · Cited by 151 · see citing works

Nuclear bodies: news insights into structure and function

Staněk, D., & Fox, A. H. (2017) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2017.05.001 · Cited by 149 · see citing works

Transcriptional Regulation of Telomerase Reverse Transcriptase (TERT) by MYC

Khattar, E., & Tergaonkar, V. (2017) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2017.00001 · Cited by 152 · see citing works

Inventory of telomerase components in human cells reveals multiple subpopulations of hTR and hTERT

Xi, L., & Cech, T. R. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku560 · Cited by 144 · see citing works

It all comes together at the ends: Telomerase structure, function, and biogenesis

Podlevsky, J. D., & Chen, J. J. ‐. (2011) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2011.11.002 · Cited by 144 · see citing works

Human telomeric proteins occupy selective interstitial sites

Yang, D., Xiong, Y., Kim, H., He, Q., Li, Y., Chen, R., & Songyang, Z. (2011) · Cell Research · doi:10.1038/cr.2011.39 · Cited by 141 · see citing works

Replication of Telomeres and the Regulation of TelomerasePreprint

Pfeiffer, V., & Lingner, J. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a010405 · Cited by 137 · see citing works

Biogenesis of spliceosomal small nuclear ribonucleoproteins

Fischer, U., Englbrecht, C., & Chari, A. (2011) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.87 · Cited by 140 · see citing works

Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms

Zhu, R., Yan, T., Feng, Y., Liu, Y., Cao, H., Peng, G., Yang, Y., Xu, Z., Liu, J., Hou, W., et al. (2021) · Cell Research · doi:10.1038/s41422-021-00573-y · Cited by 140 · see citing works

Dyskeratosis congenita as a disorder of telomere maintenance

Nelson, N. D., & Bertuch, A. A. (2011) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2011.06.008 · Cited by 138 · see citing works

Telomere length regulation: coupling DNA end processing to feedback regulation of telomerase

Shore, D., & Bianchi, A. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.195 · Cited by 138 · see citing works

Telomere Length and Oxidative Stress and Its Relation with Metabolic Syndrome Components in the Aging

Gavia-García, G., Rosado-Pérez, J., Arista-Ugalde, T. L., Aguíñiga-Sánchez, I., Santiago‐Osorio, E., & Mendoza-Núñez, V. M. (2021) · Biology · doi:10.3390/biology10040253 · Cited by 141 · see citing works

WRAP53 Is Essential for Cajal Body Formation and for Targeting the Survival of Motor Neuron Complex to Cajal Bodies

Mahmoudi, S., Henriksson, S., Weibrecht, I., Smith, S., Söderberg, O., Strömblad, S., Wiman, K. G., & Farnebo, M. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000521 · Cited by 135 · see citing works

Structure of active dimeric human telomerase

Sauerwald, A., Sandin, S., Cristofari, G., Scheres, S. H. W., Lingner, J., & Rhodes, D. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2530 · Cited by 129 · see citing works

Beginning at the ends: telomeres and human disease

Savage, S. A. (2018) · F1000Research · doi:10.12688/f1000research.14068.1 · Cited by 124 · see citing works

Telomerase Recruitment Requires both TCAB1 and Cajal Bodies Independently

Stern, J. L., Zyner, K. G., Pickett, H. A., Cohen, S. B., & Bryan, T. M. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00379-12 · Cited by 127 · see citing works

1,25-Dihydroxyvitamin D3 Suppresses Telomerase Expression and Human Cancer Growth through MicroRNA-498

Kasiappan, R., Shen, Z., Tse, A. K., Jinwal, U. K., Tang, J., Lungchukiet, P., Sun, Y., Kruk, P. A., Nicosia, S. V., Zhang, X. M., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.407189 · Cited by 125 · see citing works

The Functional Meaning of 5′UTR in Protein-Coding Genes

Ryczek, N., Łyś, A., & Makałowska, I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032976 · Cited by 128 · see citing works

Nuclear bodies: new insights into assembly/dynamics and disease relevance

Sleeman, J., & Trinkle‐Mulcahy, L. (2014) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.03.004 · Cited by 125 · see citing works

Evolutionary perspectives of telomerase RNA structure and function

Podlevsky, J. D., & Chen, J. J. ‐. (2016) · RNA Biology · doi:10.1080/15476286.2016.1205768 · Cited by 121 · see citing works

Inherited bone marrow failure associated with germline mutation of ACD, the gene encoding telomere protein TPP1

Guo, Y., Kartawinata, M., Li, J., Pickett, H. A., Teo, J., Kilo, T., Barbaro, P., Keating, B. J., Chen, Y., Tian, L., et al. (2014) · Blood · doi:10.1182/blood-2014-08-596445 · Cited by 119 · see citing works

New prospects for targeting telomerase beyond the telomere

Arndt, G. M., & MacKenzie, K. L. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.55 · Cited by 120 · see citing works

Live Cell Imaging of Telomerase RNA Dynamics Reveals Cell Cycle-Dependent Clustering of Telomerase at Elongating Telomeres

Gallardo, F., Laterreur, N., Cusanelli, E., Ouenzar, F., Querido, E., Wellinger, R. J., & Chartrand, P. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.09.020 · Cited by 118 · see citing works

Control of telomerase action at human telomeres

Hockemeyer, D. F., & Collins, K. (2015) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3083 · Cited by 118 · see citing works

Variation at theTERTlocus and predisposition for cancer

Baird, D. M. (2010) · Expert Reviews in Molecular Medicine · doi:10.1017/s146239941000147x · Cited by 115 · see citing works

Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects

Shukla, S., Schmidt, J. C., Goldfarb, K. C., Cech, T. R., & Parker, R. (2016) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3184 · Cited by 114 · see citing works

Sizing the ends: Normal length of human telomeres

Samassékou, O., Gadji, M., Drouin, R., & Yan, J. (2010) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2010.07.005 · Cited by 115 · see citing works

Telomeres and telomerase as therapeutic targets to prevent and treat age-related diseases

Bär, C., & Blasco, M. A. (2016) · F1000Research · doi:10.12688/f1000research.7020.1 · Cited by 115 · see citing works

Specificity and Stoichiometry of Subunit Interactions in the Human Telomerase Holoenzyme Assembled In Vivo

Egan, E. D., & Collins, K. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00151-10 · Cited by 111 · see citing works

Telomere and Telomerase Therapeutics in Cancer

Xu, Y., & Goldkorn, A. (2016) · Genes · doi:10.3390/genes7060022 · Cited by 109 · see citing works

The regulations of telomerase reverse transcriptase (TERT) in cancer

Liu, M.-D., Zhang, Y., Jian, Y.-P., Gu, L.-T., Zhang, D., Zhou, H.-L., Wang, Y.-S., & Xu, Z.-X. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06454-7 · Cited by 116 · see citing works

Small-Molecule PAPD5 Inhibitors Restore Telomerase Activity in Patient Stem Cells

Nagpal, N., Wang, J., Zeng, J., Lo, E., Moon, D. H., Luk, K., Braun, R. O., Burroughs, L. M., Keel, S. B., Reilly, C., et al. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.03.016 · Cited by 105 · see citing works

The 5′ Guanosine Tracts of Human Telomerase RNA Are Recognized by the G-Quadruplex Binding Domain of the RNA Helicase DHX36 and Function To Increase RNA Accumulation

Sexton, A. N., & Collins, K. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01033-10 · Cited by 107 · see citing works

Identification of human TERT elements necessary for telomerase recruitment to telomeres

Schmidt, J. C., Dalby, A. B., & Cech, T. R. (2014) · eLife · doi:10.7554/elife.03563 · Cited by 104 · see citing works

Molecular mechanisms of telomere biology disorders

Grill, S., & Nandakumar, J. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev120.014017 · Cited by 2 · see citing works

Functional Analysis of Human Hub Proteins and Their Interactors Involved in the Intrinsic Disorder-Enriched Interactions

Hu, G., Wu, Z., Uversky, V. N., & Kurgan, L. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122761 · Cited by 105 · see citing works

Telomerase Activity and Telomere Length in Male Germ Cells

Öztürk, S. (2015) · Biology of Reproduction · doi:10.1095/biolreprod.114.124008 · Cited by 104 · see citing works

Telomerase and Telomere-Associated Proteins: Structural Insights into Mechanism and Evolution

Lewis, K. A., & Wuttke, D. S. (2012) · Structure · doi:10.1016/j.str.2011.10.017 · Cited by 101 · see citing works

The Coilin Interactome Identifies Hundreds of Small Noncoding RNAs that Traffic through Cajal Bodies

Machyna, M., Kehr, S., Straube, K., Kappei, D., Buchholz, F., Butter, F., Ule, J., Jana Hertel, A., Stadler, P. F., & Neugebauer, K. M. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.10.004 · Cited by 103 · see citing works

Transcriptional and epigenetic regulation of the p53 tumor suppressor gene

Saldaña-Meyer, R., & Targa, F. R. (2011) · Epigenetics · doi:10.4161/epi.6.9.16683 · Cited by 101 · see citing works

Dyskerin: an essential pseudouridine synthase with multifaceted roles in ribosome biogenesis, splicing, and telomere maintenance

Garus, A., & Autexier, C. (2021) · RNA · doi:10.1261/rna.078953.121 · Cited by 101 · see citing works

RNA modification in Cajal bodies

Meier, U. T. (2016) · RNA Biology · doi:10.1080/15476286.2016.1249091 · Cited by 97 · see citing works

Genomic sites hypersensitive to ultraviolet radiation

Premi, S., Han, L., Mehta, S., Knight, J., Zhao, D., Palmatier, M. A., Kornacker, K., & Brash, D. E. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1907860116 · Cited by 95 · see citing works

Preeclampsia: novel insights from global RNA profiling of trophoblast subpopulations

Gormley, M. J., Ona, K. R., Kapidzic, M., Garrido‐Gómez, T., Zdravkovic, T., & Fisher, S. J. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.03.017 · Cited by 95 · see citing works

Commonly used tag combinations for tandem affinity purification

Li, Y. (2010) · Biotechnology and Applied Biochemistry · doi:10.1042/ba20090273 · Cited by 95 · see citing works

The Role of Nuclear Bodies in Gene Expression and Disease

Morimoto, M., & Boerkoel, C. F. (2013) · Biology · doi:10.3390/biology2030976 · Cited by 96 · see citing works

Reduced Viability, Fertility and Fecundity in Mice Lacking the Cajal Body Marker Protein, Coilin

Walker, M. P., Tian, L., & Matera, A. G. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006171 · Cited by 93 · see citing works

Telomerase in Cancer: Function, Regulation, and Clinical Translation

Robinson, N. J., & Schiemann, W. P. (2022) · Cancers · doi:10.3390/cancers14030808 · Cited by 94 · see citing works

Processive and Distributive Extension of Human Telomeres by Telomerase under Homeostatic and Nonequilibrium Conditions

Zhao, Y. B., Abreu, E. B., Kim, J., Stadler, G., Eskiocak, U., Terns, M. P., Terns, R. M., Shay, J. W., & Wright, W. E. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.03.020 · Cited by 90 · see citing works

Short telomeres: from dyskeratosis congenita to sporadic aplastic anemia and malignancy

Gramatges, M. M., & Bertuch, A. A. (2013) · Translational research · doi:10.1016/j.trsl.2013.05.003 · Cited by 89 · see citing works

Telomeres: Implications for Cancer Development

Bernal, A., & Tusell, L. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19010294 · Cited by 86 · see citing works

In Brief

(2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2647

TCAB1: Driving telomerase to Cajal bodies

Venteicher, A. S., & Artandi, S. E. (2009) · Cell Cycle · doi:10.4161/cc.8.9.8288 · Cited by 73 · see citing works

Human Telomerase RNA Accumulation in Cajal Bodies Facilitates Telomerase Recruitment to Telomeres and Telomere Elongation

Cristofari, G., Adolf, E., Reichenbach, P., Sikora, K. O., Terns, R. M., Terns, M. P., & Lingner, J. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.07.020 · Cited by 185 · see citing works

Cell Cycle-dependent Recruitment of Telomerase RNA and Cajal Bodies to Human Telomeres

Jády, B. E., Richard, P., Bertrand, É., & Kiss, T. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-09-0904 · Cited by 204 · see citing works

Catalytically active telomerase holoenzyme is assembled in the dense fibrillar component of the nucleolus during S phase

Lee, J. H., Lee, Y. S., Jeong, S. A., Khadka, P., Roth, J., & Chung, I. K. (2013) · Histochemistry and Cell Biology · doi:10.1007/s00418-013-1166-x · Cited by 48 · see citing works