The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes
Open accessAbstract
TCF and SOX proteins belong to the high mobility group box transcription factor family. Whereas TCFs, the transcriptional effectors of the Wnt pathway, have been widely implicated in the development, homeostasis and disease of the intestine epithelium, little is known about the function of the SOX proteins in this tissue. Here, we identified SOX9 in a SOX expression screening in the mouse fetal intestine. We report that the SOX9 protein is expressed in the intestinal epithelium in a pattern characteristic of Wnt targets. We provide in vitro and in vivo evidence that a bipartite β-catenin/TCF4 transcription factor, the effector of the Wnt signaling pathway, is required for SOX9 expression in epithelial cells. Finally, in colon epithelium-derived cells, SOX9 transcriptionally represses the CDX2 and MUC2 genes, normally expressed in the mature villus cells of the intestinal epithelium, and may therefore contribute to the Wnt-dependent maintenance of a progenitor cell phenotype.
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Cites
Akiyama, H., Chaboissier, M.-C., Martin, J. F., Schedl, A., & de Crombrugghe, B. (2002) · Genes & Development · doi:10.1101/gad.1017802 · Cited by 1,721
Colorectal Cancer in Mice Genetically Deficient in the Mucin Muc2
Velcich, A., Yang, W., Heyer, J., Fragale, A., Nicholas, C., Viani, S., Kucherlapati, R., Lipkin, M., Yang, K., & Augenlicht, L. (2002) · Science · doi:10.1126/science.1069094 · Cited by 936
Vertebrate neurogenesis is counteracted by Sox1–3 activity
Bylund, M., Andersson, E., Novitch, B. G., & Muhr, J. (2003) · Nature Neuroscience · doi:10.1038/nn1131 · Cited by 825
The Sox9 transcription factor determines glial fate choice in the developing spinal cord
Stolt, C. C., Lommes, P., Sock, E., Chaboissier, M.-C., Schedl, A., & Wegner, M. (2003) · Genes & Development · doi:10.1101/gad.259003 · Cited by 636
A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors.
Fodde, R., Edelmann, W., Yang, K., van Leeuwen, C., Carlson, C., Renault, B., Breukel, C., Alt, E., Lipkin, M., & Khan, P. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.19.8969 · Cited by 531 · cited 2×
“Moreover, targeted mutations of APC or -catenin are sufficient to initiate tumorigenesis in the mouse (Fodde et al., 1994; Shibata et al., 1997; Harada et al., 1999), highlighting the importance of the Wnt pathway in the development of cancer.”
BackgroundThe transcription factor Sox9 is required for cranial neural crest development in Xenopus
Spokony, R. F., Aoki, Y., Saint-Germain, N., Magner-Fink, E., & Saint-Jeannet, J.-P. (2002) · Development · doi:10.1242/dev.129.2.421 · Cited by 295
Cited by
Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis
Bevins, C. L., & Salzman, N. H. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2546 · Cited by 1,238
Canonical Wnt/β-Catenin Signaling Prevents Osteoblasts from Differentiating into Chondrocytes
Hill, T. P., Später, D., Taketo, M. M., Birchmeier, W., & Hartmann, C. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.02.013 · Cited by 1,084
SOX9 is required for maintenance of the pancreatic progenitor cell pool
Seymour, P. A., Freude, K. K., Tran, M. N., Mayes, E. E., Jensen, J., Kist, R., Scherer, G., & Sander, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609217104 · Cited by 567
Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer
Rodilla, V., Villanueva, A., Obrador-Hevia, A., Robert-Moreno, À., Fernández-Majada, V., Grilli, A., López-Bigas, N., Bellora, N., Albà, M. M., Torres, F., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813221106 · Cited by 384
NOTUM from Apc-mutant cells biases clonal competition to initiate cancer
Flanagan, D. J., Pentinmikko, N., Luopajärvi, K., Willis, N. J., Gilroy, K., Raven, A. P., Mcgarry, L., Englund, J. I., Webb, A. T., Scharaw, S., et al. (2021) · Nature · doi:10.1038/s41586-021-03525-z · Cited by 255
Self-citation
Metadata
- Authors
- Blache, P., van de Wetering, M., Duluc, I., Domon, C., Berta, P., Freund, J.-N., Clevers, H., & Jay, P.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2004-07-05
- Volume
- 166
- Issue
- 1
- Pages
- 37-47
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2139419405
- Cited by
- 506
- References
- 6
- FWCI
- 5.69
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes. https://app.cochat.ai/papers/10.1083/jcb.200311021
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- Blache, P., van de Wetering, M., Duluc, I., Domon, C., Berta, P., Freund, J.-N., Clevers, H., & Jay, P. (2004). SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200311021
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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