The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.
Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation
Open accessAbstract
Plakophilins are proteins of the armadillo family that function in embryonic development and in the adult, and when mutated can cause disease. We have ablated the plakophilin 2 gene in mice. The resulting mutant mice exhibit lethal alterations in heart morphogenesis and stability at mid-gestation (E10.5–E11), characterized by reduced trabeculation, disarrayed cytoskeleton, ruptures of cardiac walls, and blood leakage into the pericardiac cavity. In the absence of plakophilin 2, the cytoskeletal linker protein desmoplakin dissociates from the plaques of the adhering junctions that connect the cardiomyocytes and forms granular aggregates in the cytoplasm. By contrast, embryonic epithelia show normal junctions. Thus, we conclude that plakophilin 2 is important for the assembly of junctional proteins and represents an essential morphogenic factor and architectural component of the heart.
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Metadata
- Authors
- Grossmann, K. S., Grund, C., Huelsken, J., Behrend, M., Erdmann, B., Franke, W. W., & Birchmeier, W.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2004-10-11
- Volume
- 167
- Issue
- 1
- Pages
- 149-160
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W1982213890
- Cited by
- 269
- References
- 75
- FWCI
- 6.23
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Grossmann, K. S., Grund, C., Huelsken, J., Behrend, M., Erdmann, B., Franke, W. W., & Birchmeier, W. (2004). Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200402096
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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