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Cited by 580

The DOI matches its Crossref record; 106 of the 106 references it cites were found in a registry or an index.

Desmosome structure, composition and function

Open access
Garrod, David, Chidgey, Martyn·2008·Biochimica et Biophysica Acta (BBA) - Biomembranes

Abstract

Desmosomes are intercellular junctions of epithelia and cardiac muscle. They resist mechanical stress because they adopt a strongly adhesive state in which they are said to be hyper-adhesive and which distinguishes them from other intercellular junctions; desmosomes are specialised for strong adhesion and their failure can result in diseases of the skin and heart. They are also dynamic structures whose adhesiveness can switch between high and low affinity adhesive states during processes such as embryonic development and wound healing, the switching being signalled by protein kinase C. Desmosomes may also act as signalling centres, regulating the availability of signalling molecules and thereby participating in fundamental processes such as cell proliferation, differentiation and morphogenesis. Here we consider the structure, composition and function of desmosomes, and their role in embryonic development and disease.

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Registry

Crossref · 10.1016/j.bbamem.2007.07.014

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Metadata

Authors
Garrod, D., & Chidgey, M.
Venue
Biochimica et Biophysica Acta (BBA) - Biomembranes
Publisher
Elsevier BV
Published
2008-03
Volume
1778
Issue
3
Pages
572-587
ISSN
0005-2736 (ISSN-L)
OpenAlex
W2169851453
Cited by
580
References
106
FWCI
8.55
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Desmosome structure, composition and function. https://app.cochat.ai/papers/10.1016/j.bbamem.2007.07.014
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Garrod, D., & Chidgey, M. (2008). Desmosome structure, composition and function. Biochimica et Biophysica Acta (BBA) - Biomembranes. https://doi.org/10.1016/j.bbamem.2007.07.014

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.