The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Clathrin- and caveolin-1–independent endocytosis
Open accessAbstract
Simian Virus 40 (SV40) has been shown to enter host cells by caveolar endocytosis followed by transport via caveosomes to the endoplasmic reticulum (ER). Using a caveolin-1 (cav-1)–deficient cell line (human hepatoma 7) and embryonic fibroblasts from a cav-1 knockout mouse, we found that in the absence of caveolae, but also in wild-type embryonic fibroblasts, the virus exploits an alternative, cav-1–independent pathway. Internalization was rapid (t1/2 = 20 min) and cholesterol and tyrosine kinase dependent but independent of clathrin, dynamin II, and ARF6. The viruses were internalized in small, tight-fitting vesicles and transported to membrane-bounded, pH-neutral organelles similar to caveosomes but devoid of cav-1 and -2. The viruses were next transferred by microtubule-dependent vesicular transport to the ER, a step that was required for infectivity. Our results revealed the existence of a virus-activated endocytic pathway from the plasma membrane to the ER that involves neither clathrin nor caveolae and that can be activated also in the presence of cav-1.
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Hammond, C., & Helenius, A. (1994) · The Journal of cell biology · doi:10.1083/jcb.126.1.41 · Cited by 443
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Cited by
Doherty, G. J., & McMahon, H. T. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.78.081307.110540 · Cited by 3,075
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Pathways of clathrin-independent endocytosis
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Metadata
- Authors
- Damm, E.-M., Pelkmans, L., Kartenbeck, J., Mezzacasa, A., Kurzchalia, T., & Helenius, A.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2005-01-24
- Volume
- 168
- Issue
- 3
- Pages
- 477-488
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2152624614
- Cited by
- 454
- References
- 1
- FWCI
- 15.58
- Type
- journal article
- Language
- en
- Open access
- green
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- Damm, E.-M., Pelkmans, L., Kartenbeck, J., Mezzacasa, A., Kurzchalia, T., & Helenius, A. (2005). Clathrin- and caveolin-1–independent endocytosis. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200407113
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