The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation
Open accessAbstract
Activating mutations in fibroblast growth factor receptor 2 (FGFR2) cause several craniosynostosis syndromes by affecting the proliferation and differentiation of osteoblasts, which form the calvarial bones. Osteoblasts respond to FGF with increased proliferation and inhibition of differentiation. We analyzed the gene expression profiles of osteoblasts expressing FGFR2 activating mutations (C342Y or S252W) and found a striking down-regulation of the expression of many Wnt target genes and a concomitant induction of the transcription factor Sox2. Most of these changes could be reproduced by treatment of osteoblasts with exogenous FGF. Wnt signals promote osteoblast function and regulate bone mass. Sox2 is expressed in calvarial osteoblasts in vivo and we show that constitutive expression of Sox2 inhibits osteoblast differentiation and causes down-regulation of the expression of numerous Wnt target genes. Sox2 associates with β-catenin in osteoblasts and can inhibit the activity of a Wnt responsive reporter plasmid through its COOH-terminal domain. Our results indicate that FGF signaling could control many aspects of osteoblast differentiation through induction of Sox2 and regulation of the Wnt–β-catenin pathway.
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Cites
High Bone Density Due to a Mutation in LDL-Receptor–Related Protein 5
Boyden, L. M., Mao, J., Belsky, J., Mitzner, L., Farhi, A., Mitnick, M. A., Wu, D., Insogna, K., & Lifton, R. P. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa013444 · Cited by 1,591
Kato, M., Patel, M. S., Levasseur, R., Lobov, I., Chang, B. H.-J., Glass, D. A., Hartmann, C., Li, L., Hwang, T.-H., Brayton, C. F., et al. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200201089 · Cited by 1,086 · cited 1×
“1067 Mice lacking LRP5 develop low bone mass and osteoporosis, and LRP5 null-osteoblasts display reduced proliferation and differentiation (Kato et al., 2002).”
BackgroundVertebrate neurogenesis is counteracted by Sox1–3 activity
Bylund, M., Andersson, E., Novitch, B. G., & Muhr, J. (2003) · Nature Neuroscience · doi:10.1038/nn1131 · Cited by 825
Cited by
Buried alive: How osteoblasts become osteocytes
Franz‐Odendaal, T. A., Hall, B. K., & Witten, P. E. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20603 · Cited by 795
Sox2+ Adult Stem and Progenitor Cells Are Important for Tissue Regeneration and Survival of Mice
Arnold, K., Sarkar, A., Yram, M. A., Polo, J. M., Bronson, R., Sengupta, S., Seandel, M., Geijsen, N., & Hochedlinger, K. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2011.09.001 · Cited by 768
Mechanisms underlying differential responses to FGF signaling
Dailey, L., Ambrosetti, D., Mansukhani, A., & Basilico, C. (2005) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2005.01.007 · Cited by 649
Self-citationOsteoblast and osteocyte: Games without frontiers
Capulli, M., Paone, R., & Rucci, N. (2014) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.05.003 · Cited by 413
Signaling networks in RUNX2‐dependent bone development
Komori, T. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22994 · Cited by 329
Metadata
- Authors
- Mansukhani, A., Ambrosetti, D., Holmes, G., Cornivelli, L., & Basilico, C.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2005-03-21
- Volume
- 168
- Issue
- 7
- Pages
- 1065-1076
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2101027724
- Cited by
- 234
- References
- 3
- FWCI
- 8.07
- Type
- journal article
- Language
- en
- Open access
- green
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- Mansukhani, A., Ambrosetti, D., Holmes, G., Cornivelli, L., & Basilico, C. (2005). Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200409182
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