The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles
Open accessAbstract
Rho-associated kinase (ROCK) I mediates signaling from Rho to the actin cytoskeleton. To investigate the in vivo functions of ROCK-I, we generated ROCK-I–deficient mice. Loss of ROCK-I resulted in failure of eyelid closure and closure of the ventral body wall, which gave rise to the eyes open at birth and omphalocele phenotypes in neonates. Most ROCK-I−/− mice died soon after birth as a result of cannibalization of the omphalocele by the mother. Actin cables that encircle the eye in the epithelial cells of the eyelid were disorganized and accumulation of filamentous actin at the umbilical ring was impaired, with loss of phosphorylation of the myosin regulatory light chain (MLC) at both sites, in ROCK-I−/− embryos. Stress fiber formation and MLC phosphorylation induced by EGF were also attenuated in primary keratinocytes from ROCK-I−/− mice. These results suggest that ROCK-I regulates closure of the eyelids and ventral body wall through organization of actomyosin bundles.
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Cites
Strain-Dependent Epithelial Defects in Mice Lacking the EGF Receptor
Sibilia, M., & Wagner, E. F. (1995) · Science · doi:10.1126/science.7618085 · Cited by 1,002
Wound healing recapitulates morphogenesis in Drosophila embryos
Wood, W., Jacinto, A., Grose, R., Woolner, S., Gale, J., Wilson, C., & Martin, P. (2002) · Nature Cell Biology · doi:10.1038/ncb875 · Cited by 435
Cited by
Rho‐kinase/ROCK: A key regulator of the cytoskeleton and cell polarity
Amano, M., Nakayama, M., & Kaibuchi, K. (2010) · Cytoskeleton · doi:10.1002/cm.20472 · Cited by 994
Rho kinase, a promising drug target for neurological disorders
Mueller, B. K., Mack, H., & Teusch, N. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1719 · Cited by 608
Rho-associated coiled-coil containing kinases (ROCK): Structure, regulation, and functions
Julian, L., & Olson, M. F. (2014) · Small GTPases · doi:10.4161/sgtp.29846 · Cited by 550
Komarova, Y. A., Kruse, K., Mehta, D., & Malik, A. B. (2017) · Circulation Research · doi:10.1161/circresaha.116.306534 · Cited by 503
Regulation of myosin II during cytokinesis in higher eukaryotes
Matsumura, F. (2005) · Trends in Cell Biology · doi:10.1016/j.tcb.2005.05.004 · Cited by 414
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Metadata
- Authors
- Shimizu, Y., Thumkeo, D., Keel, J., Ishizaki, T., Oshima, H., Oshima, M., Noda, Y., Matsumura, F., Taketo, M. M., & Narumiya, S.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2005-03-07
- Volume
- 168
- Issue
- 6
- Pages
- 941-953
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2097921546
- Cited by
- 304
- References
- 2
- FWCI
- 6.68
- Type
- journal article
- Language
- en
- Open access
- green
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- Shimizu, Y., Thumkeo, D., Keel, J., Ishizaki, T., Oshima, H., Oshima, M., Noda, Y., Matsumura, F., Taketo, M. M., & Narumiya, S. (2005). ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200411179
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