The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
The mechanisms and dynamics of αvβ3 integrin clustering in living cells
Open accessAbstract
During cell migration, the physical link between the extracellular substrate and the actin cytoskeleton mediated by receptors of the integrin family is constantly modified. We analyzed the mechanisms that regulate the clustering and incorporation of activated αvβ3 integrins into focal adhesions. Manganese (Mn2+) or mutational activation of integrins induced the formation of de novo F-actin–independent integrin clusters. These clusters recruited talin, but not other focal adhesion adapters, and overexpression of the integrin-binding head domain of talin increased clustering. Integrin clustering required immobilized ligand and was prevented by the sequestration of phosphoinositole-4,5-bisphosphate (PI(4,5)P2). Fluorescence recovery after photobleaching analysis of Mn2+-induced integrin clusters revealed increased integrin turnover compared with mature focal contacts, whereas stabilization of the open conformation of the integrin ectodomain by mutagenesis reduced integrin turnover in focal contacts. Thus, integrin clustering requires the formation of the ternary complex consisting of activated integrins, immobilized ligands, talin, and PI(4,5)P2. The dynamic remodeling of this ternary complex controls cell motility.
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Vogel, V., & Sheetz, M. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1890 · Cited by 2,328
Vinculin controls focal adhesion formation by direct interactions with talin and actin
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Mechanically Activated Integrin Switch Controls α 5 β 1 Function
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Metadata
- Authors
- Cluzel, C., Saltel, F., Lussi, J., Paulhe, F., Imhof, B. A., & Wehrle-Haller, B.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2005-10-24
- Volume
- 171
- Issue
- 2
- Pages
- 383-392
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2120832308
- Cited by
- 351
- References
- 50
- FWCI
- 7.60
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Cluzel, C., Saltel, F., Lussi, J., Paulhe, F., Imhof, B. A., & Wehrle-Haller, B. (2005). The mechanisms and dynamics of αvβ3 integrin clustering in living cells. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200503017
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
