The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Mechanically Activated Integrin Switch Controls α 5 β 1 Function
Abstract
The cytoskeleton, integrin-mediated adhesion, and substrate stiffness control a common set of cell functions required for development and homeostasis that are often deranged in cancer. The connection between these mechanical elements and chemical signaling processes is not known. Here, we show that α 5 β 1 integrin switches between relaxed and tensioned states in response to myosin II–generated cytoskeletal force. Force combines with extracellular matrix stiffness to generate tension that triggers the integrin switch. This switch directly controls the α 5 β 1 -fibronectin bond strength through engaging the synergy site in fibronectin and is required to generate signals through phosphorylation of focal adhesion kinase. In the context of tissues, this integrin switch connects cytoskeleton and extracellular matrix mechanics to adhesion-dependent motility and signaling pathways.
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Cites
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Focal Contacts as Mechanosensors
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Force Sensing by Mechanical Extension of the Src Family Kinase Substrate p130Cas
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Cited by
The extracellular matrix at a glance
Frantz, C., Stewart, K. M., & Weaver, V. M. (2010) · Journal of Cell Science · doi:10.1242/jcs.023820 · Cited by 4,334
Non-muscle myosin II takes centre stage in cell adhesion and migration
Vicente-Manzanares, M., Ma, X., Adelstein, R. S., & Horwitz, A. R. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2786 · Cited by 2,032
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Integrins as biomechanical sensors of the microenvironment
Kechagia, J. Z., Ivaska, J., & Roca-Cusachs, P. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0134-2 · Cited by 1,311
The final steps of integrin activation: the end game
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Metadata
- Authors
- Friedland, J. C., Lee, M. H., & Boettiger, D.
- Venue
- Science
- Published
- 2009-01-30
- Volume
- 323
- Issue
- 5914
- Pages
- 642-644
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1999765951
- Cited by
- 717
- References
- 23
- FWCI
- 49.45
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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