The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
A Rac switch regulates random versus directionally persistent cell migration
Open accessAbstract
Directional migration moves cells rapidly between points, whereas random migration allows cells to explore their local environments. We describe a Rac1 mechanism for determining whether cell patterns of migration are intrinsically random or directionally persistent. Rac activity promoted the formation of peripheral lamellae that mediated random migration. Decreasing Rac activity suppressed peripheral lamellae and switched the cell migration patterns of fibroblasts and epithelial cells from random to directionally persistent. In three-dimensional rather than traditional two-dimensional cell culture, cells had a lower level of Rac activity that was associated with rapid, directional migration. In contrast to the directed migration of chemotaxis, this intrinsic directional persistence of migration was not mediated by phosphatidylinositol 3′-kinase lipid signaling. Total Rac1 activity can therefore provide a regulatory switch between patterns of cell migration by a mechanism distinct from chemotaxis.
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Cites
Cell Migration: A Physically Integrated Molecular Process
Lauffenburger, D. A., & Horwitz, A. F. (1996) · Cell · doi:10.1016/s0092-8674(00)81280-5 · Cited by 3,915
Taking Cell-Matrix Adhesions to the Third Dimension
Cukierman, E., Pankov, R., Stevens, D. R., & Yamada, K. M. (2001) · Science · doi:10.1126/science.1064829 · Cited by 3,027
Self-citationRational design and characterization of a Rac GTPase-specific small molecule inhibitor
Gao, Y., Dickerson, J. B., Guo, F., Zheng, J., & Zheng, Y. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307512101 · Cited by 1,091
Cdc42 regulates GSK-3β and adenomatous polyposis coli to control cell polarity
Etienne-Manneville, S., & Hall, A. (2003) · Nature · doi:10.1038/nature01423 · Cited by 835
Rac2 Specificity in Macrophage Integrin Signaling
Pradip, D., Peng, X., & Durden, D. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306491200 · Cited by 49
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Yamada, K. M., & Cukierman, E. (2007) · Cell · doi:10.1016/j.cell.2007.08.006 · Cited by 1,751
Self-citationBerrier, A. L., & Yamada, K. M. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21237 · Cited by 957
Self-citationAdhesion signaling – crosstalk between integrins, Src and Rho
Huveneers, S., & Danen, E. H. J. (2009) · Journal of Cell Science · doi:10.1242/jcs.039446 · Cited by 852
One-dimensional topography underlies three-dimensional fibrillar cell migration
Doyle, A. D., Wang, F. W., Matsumoto, K., & Yamada, K. M. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200810041 · Cited by 732
Self-citationEGFR in Cancer: Signaling Mechanisms, Drugs, and Acquired Resistance
Uribe, M. L., Marrocco, I., & Yarden, Y. (2021) · Cancers · doi:10.3390/cancers13112748 · Cited by 604
Metadata
- Authors
- Pankov, R., Endo, Y., Even-Ram, S., Araki, M., Clark, K., Cukierman, E., Matsumoto, K., & Yamada, K. M.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2005-08-29
- Volume
- 170
- Issue
- 5
- Pages
- 793-802
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2123129088
- Cited by
- 453
- References
- 5
- FWCI
- 9.80
- Type
- journal article
- Language
- en
- Open access
- green
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- Pankov, R., Endo, Y., Even-Ram, S., Araki, M., Clark, K., Cukierman, E., Matsumoto, K., & Yamada, K. M. (2005). A Rac switch regulates random versus directionally persistent cell migration. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200503152
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