The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response
Open accessAbstract
Upon the accumulation of unfolded proteins in the mammalian endoplasmic reticulum (ER), X-box binding protein 1 (XBP1) premessenger RNA (premRNA) is converted to mature mRNA by unconventional splicing that is mediated by the endonuclease inositol-requiring enzyme 1. The transcription factor protein (p) XBP1 spliced (S), which is translated from mature XBP1 mRNA, contains the nuclear localization signal and the transcriptional activation domain and activates the transcription of target genes, including those encoding ER chaperones in the nucleus. We show that pXBP1 unspliced (U) encoded in XBP1 pre-mRNA was constitutively expressed and markedly accumulated at the recovery phase of ER stress. pXBP1(U) contained the nuclear exclusion signal instead of the transcriptional activation domain and shuttled between the nucleus and the cytoplasm. Interestingly, pXBP1(U) formed a complex with pXBP1(S), and the pXBP1(U)–pXBP1(S) complex was sequestered from the nucleus. Moreover, the complex was rapidly degraded by proteasomes because of the degradation motif contained in pXBP1(U). Thus, pXBP1(U) is a negative feedback regulator of pXBP1(S), which shuts off the transcription of target genes during the recovery phase of ER stress.
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Cites
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
ER Stress Induces Cleavage of Membrane-Bound ATF6 by the Same Proteases that Process SREBPs
Ye, J., Rawson, R. B., Komuro, R., Chen, X., Davé, U. P., Prywes, R., Brown, M. S., & Goldstein, J. L. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00133-7 · Cited by 1,871
Yoshida, H., Okada, T., Haze, K., Yanagi, H., Yura, T., Negishi, M., & Mori, K. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.18.6755-6767.2000 · Cited by 934
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Cited by
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress
Tabas, I., & Ron, D. (2011) · Nature Cell Biology · doi:10.1038/ncb0311-184 · Cited by 2,598
Yoshida, H. (2007) · The FEBS Journal · doi:10.1111/j.1742-4658.2007.05639.x · Cited by 1,086
Self-citationXBP1 Controls Diverse Cell Type- and Condition-Specific Transcriptional Regulatory Networks
Acosta-Alvear, D., Zhou, Y., Blais, A., Tsikitis, M., Lents, N. H., Arias, C., Lennon, C. J., Kluger, Y., & Dynlacht, B. D. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.06.011 · Cited by 850
The endoplasmic reticulum stress response in immunity and autoimmunity
Todd, D. J., Lee, A.-H., & Glimcher, L. H. (2008) · Nature Reviews Immunology · doi:10.1038/nri2359 · Cited by 623
Deng, Y., Humbert, S., Liu, J.-X., Srivastava, R., Rothstein, S. J., & Howell, S. H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102117108 · Cited by 473
Metadata
- Authors
- Yoshida, H., Oku, M., Suzuki, M., & Mori, K.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2006-02-06
- Volume
- 172
- Issue
- 4
- Pages
- 565-575
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2088510522
- Cited by
- 415
- References
- 3
- FWCI
- 9.74
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response. https://app.cochat.ai/papers/10.1083/jcb.200508145
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- Yoshida, H., Oku, M., Suzuki, M., & Mori, K. (2006). pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200508145
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