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Cited by 186Cellular transport and secretionNeurogenesis and neuroplasticity mechanismsCaveolin-1 and cellular processes

Neuron to glia signaling triggers myelin membrane exocytosis from endosomal storage sites

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Trajkovic, Katarina, Dhaunchak, Ajit Singh, Goncalves, José T., Wenzel, Dirk, Schneider, Anja, Bunt, Gertrude, Nave, Klaus-Armin, Simons, Mikael·2006·The Journal of Cell Biology
DOI 10.1083/jcb.200509022PMC PMC2063736
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Abstract

During vertebrate brain development, axons are enwrapped by myelin, an insulating membrane produced by oligodendrocytes. Neuron-derived signaling molecules are temporally and spatially required to coordinate oligodendrocyte differentiation. In this study, we show that neurons regulate myelin membrane trafficking in oligodendrocytes. In the absence of neurons, the major myelin membrane protein, the proteolipid protein (PLP), is internalized and stored in late endosomes/lysosomes (LEs/Ls) by a cholesterol-dependent and clathrin-independent endocytosis pathway that requires actin and the RhoA guanosine triphosphatase. Upon maturation, the rate of endocytosis is reduced, and a cAMP-dependent neuronal signal triggers the transport of PLP from LEs/Ls to the plasma membrane. These findings reveal a fundamental and novel role of LEs/Ls in oligodendrocytes: to store and release PLP in a regulated fashion. The release of myelin membrane from LEs/Ls by neuronal signals may represent a mechanism to control myelin membrane growth.

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  • At least five other PD-associated genes (LRRK2, UCHL2, VCP35, DJ-1, and SNCA) affect CMA.

    “At least five other genes that are associated with PD (but not LSDs) also affect CMA: LRRK2, UCHL2, VCP35, DJ-1, and SNCA, which encodes alpha-synuclein.149–153”

    From The lysosome and proteostatic stress at the intersection of pediatric neurological disorders and adult neurodegenerative diseases (2025) · cites this paper as [153]

    The Results section discusses neuronal regulation of myelin proteolipid protein trafficking, not Parkinson’s disease genes or chaperone-mediated autophagy. Searches for the listed genes, CMA, and alpha-synuclein found no passage addressing the claim in our copy; page numbers were not available. (LLM, conf=0.78)

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Cited by

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Authors
Trajkovic, K., Dhaunchak, A. S., Goncalves, J. T., Wenzel, D., Schneider, A., Bunt, G., Nave, K.-A., & Simons, M.
Affiliations
  • 1Centre for Biochemistry and Molecular Cell Biology, University of Göttingen, 37073 Göttingen, Germany
  • Max Planck Institute of Experimental Medicine (DE)
  • 2Max-Planck-Institute for Experimental Medicine, 37075 Göttingen, Germany
  • University of Göttingen (DE)
ORCID
Venue
The Journal of Cell Biology
Publisher
Rockefeller University Press
Published
2006-03-06
Volume
172
Issue
6
Pages
937-948
ISSN
  • 0021-9525 (ISSN-L)
  • 1540-8140
DOI
10.1083/jcb.200509022
PMC
PMC2063736
OpenAlex
W2102434171
Cited by
186
References
3
Citations by year
2026: 5 · 2025: 6 · 2024: 9 · 2023: 4 · 2022: 5 · 2021: 4 · 2020: 6 · 2019: 10 · 2018: 8 · 2017: 4 · 2016: 12 · 2015: 7 · 2014: 10 · 2013: 11 · 2012: 9
FWCI
6.91
Type
journal article
Language
en
Open access
Licence
cc-by-nc-sa
Locations
  • The Journal of Cell Biology (publishedVersion)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
  • GRO (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
Keywords
oligodendrocytes, proteolipid protein, neuron-glia signaling, late endosomes, lysosomes, endocytosis, RhoA, cAMP signaling, brain development
MeSH terms
Cyclic AMP, Adenosine Triphosphate, Animals, Brain, Cell Communication, Cell Differentiation, Cells, Cultured, Endocytosis, Energy Metabolism, Exocytosis, Myelin Sheath, Neurons, Oligodendroglia, Endosomes, Signal Transduction, Coculture Techniques, Myelin Proteolipid Protein, rhoA GTP-Binding Protein, Protein Transport, Microscopy, Electron, Transmission, Mice

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