The Mystery and Magic of Glia: A Perspective on Their Roles in Health and Disease

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827 · see citing works

ATP mediates rapid microglial response to local brain injury in vivo

Davalos, D., Grutzendler, J., Yang, G., Kim, J. V., Zuo, Y., Jung, S., Littman, D. R., Dustin, M. L., & Gan, W.-B. (2005) · Nature Neuroscience · doi:10.1038/nn1472 · Cited by 3,913 · see citing works

Microglia: Active sensor and versatile effector cells in the normal and pathologic brain

Hanisch, U.-K., & Kettenmann, H. (2007) · Nature Neuroscience · doi:10.1038/nn1997 · Cited by 3,676 · see citing works

The Classical Complement Cascade Mediates CNS Synapse Elimination

Stevens, B., Allen, N. J., Vazquez, L. E., Howell, G. R., Christopherson, K. S., Nouri, N., Micheva, K. D., Mehalow, A. K., Huberman, A. D., Stafford, B., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.036 · Cited by 3,313 · see citing works

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

Zlokovic, B. V. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.003 · Cited by 3,280 · see citing works

A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function

Cahoy, J. D., Emery, B., Kaushal, A., Foo, L. C., Zamanian, J. L., Christopherson, K. S., Xing, Y., Lubischer, J. L., Krieg, P. A., Krupenko, S. A., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4178-07.2008 · Cited by 3,129 · see citing works

Regeneration beyond the glial scar

Silver, J., & Miller, J. H. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1326 · Cited by 3,090 · see citing works

Tripartite synapses: glia, the unacknowledged partner

Araque, A., Parpura, V., Sanzgiri, R. P., & Haydon, P. G. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01349-6 · Cited by 2,529 · see citing works

Synaptic scaling mediated by glial TNF-α

Stellwagen, D., & Malenka, R. C. (2006) · Nature · doi:10.1038/nature04671 · Cited by 1,715 · see citing works

CNS synaptogenesis promoted by glia-derived cholesterol

Mauch, D. H., Nägler, K., Schumacher, S., Göritz, C., Müller, E.-C., Otto, A., & Pfrieger, F. W. (2001) · Science · doi:10.1126/science.294.5545.1354 · Cited by 1,711 · see citing works

Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis

Christopherson, K. S., Ullian, E. M., Stokes, C. C. A., Mullowney, C. E., Hell, J. W., Agah, A., Lawler, J., Mosher, D. F., Bornstein, P., & Barres, B. A. (2005) · Cell · doi:10.1016/j.cell.2004.12.020 · Cited by 1,688 · see citing works

Protoplasmic Astrocytes in CA1 Stratum Radiatum Occupy Separate Anatomical Domains

Bushong, E. A., Martone, M. E., Jones, Y. Z., & Ellisman, M. H. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-01-00183.2002 · Cited by 1,578 · see citing works

Endothelial Cells Stimulate Self-Renewal and Expand Neurogenesis of Neural Stem Cells

Shen, Q., Goderie, S. K., Jin, L., Karanth, N., Sun, Y., Abramova, N. E., Vincent, P. A., Pumiglia, K. M., & Temple, S. (2004) · Science · doi:10.1126/science.1095505 · Cited by 1,538 · see citing works

1,026 Experimental treatments in acute stroke

O’Collins, V. E., Macleod, M. R., Donnan, G. A., Horky, L. L., van der Worp, H. B., & Howells, D. W. (2006) · Annals of Neurology · doi:10.1002/ana.20741 · Cited by 1,453 · see citing works

Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation

Zonta, M., Angulo, M. C., Gobbo, S., Rosengarten, B., Hossmann, K.-A., Pozzan, T., & Carmignoto, G. (2002) · Nature Neuroscience · doi:10.1038/nn980 · Cited by 1,446 · see citing works

Control of Synapse Number by Glia

Ullian, E. M., Sapperstein, S. K., Christopherson, K. S., & Barres, B. A. (2001) · Science · doi:10.1126/science.291.5504.657 · Cited by 1,380 · see citing works

Astrocytic Purinergic Signaling Coordinates Synaptic Networks

Pascual, O., Casper, K. B., Kubera, C., Zhang, J., Revilla-Sanchez, R., Sul, J.-Y., Takano, H., Moss, S. J., McCarthy, K., & Haydon, P. G. (2005) · Science · doi:10.1126/science.1116916 · Cited by 1,280 · see citing works

Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons

Nagai, M., Re, D. B., Nagata, T., Chalazonitis, A., Jessell, T. M., Wichterle, H., & Przedborski, S. (2007) · Nature Neuroscience · doi:10.1038/nn1876 · Cited by 1,220 · see citing works

Leukocyte Infiltration, Neuronal Degeneration, and Neurite Outgrowth after Ablation of Scar-Forming, Reactive Astrocytes in Adult Transgenic Mice

Bush, T. G., Puvanachandra, N., Horner, C. H., Polito, A., Ostenfeld, T., Svendsen, C. N., Mucke, L., Johnson, M. H., & Sofroniew, M. V. (1999) · Neuron · doi:10.1016/s0896-6273(00)80781-3 · Cited by 1,116 · see citing works

Imaging large-scale neural activity with cellular resolution in awake, mobile mice

Dombeck, D. A., Khabbaz, A. N., Collman, F., Adelman, T. L., & Tank, D. W. (2007) · Neuron · doi:10.1016/j.neuron.2007.08.003 · Cited by 1,099 · see citing works

A specialized vascular niche for adult neural stem cells

Tavazoie, M., Van der Veken, L., Silva-Vargas, V., Louissaint, M., Colonna, L., Zaidi, B., Garcia-Verdugo, J. M., & Doetsch, F. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.07.025 · Cited by 1,033 · see citing works

TNFα promotes proliferation of oligodendrocyte progenitors and remyelination

Arnett, H. A., Mason, J., Marino, M., Suzuki, K., Matsushima, G. K., & Ting, J. P.-Y. (2001) · Nature Neuroscience · doi:10.1038/nn738 · Cited by 1,012 · see citing works

Glia-Derived d-Serine Controls NMDA Receptor Activity and Synaptic Memory

Panatier, A., Theodosis, D. T., Mothet, J.-P., Touquet, B., Pollegioni, L., Poulain, D. A., & Oliet, S. H. R. (2006) · Cell · doi:10.1016/j.cell.2006.02.051 · Cited by 934 · see citing works

Three-Dimensional Relationships between Hippocampal Synapses and Astrocytes

Ventura, R., & Harris, K. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-16-06897.1999 · Cited by 900 · see citing works

Functional requirement for class I MHC in CNS development and plasticity

Huh, G. S., Boulanger, L. M., Du, H., Riquelme, P. A., Brotz, T. M., & Shatz, C. J. (2000) · Science · doi:10.1126/science.290.5499.2155 · Cited by 828 · see citing works

Non–cell autonomous effect of glia on motor neurons in an embryonic stem cell–based ALS model

Di Giorgio, F. P., Carrasco, M. A., Siao, M. C., Maniatis, T., & Eggan, K. (2007) · Nature Neuroscience · doi:10.1038/nn1885 · Cited by 799 · see citing works

Synaptic Efficacy Enhanced by Glial Cells in Vitro

Pfrieger, F. W., & Barres, B. A. (1997) · Science · doi:10.1126/science.277.5332.1684 · Cited by 793 · see citing works

Astrocytes promote myelination in response to electrical impulses

Ishibashi, T., Dakin, K. A., Stevens, B., Lee, P. R., Kozlov, S. V., Stewart, C. L., & Fields, R. D. (2006) · Neuron · doi:10.1016/j.neuron.2006.02.006 · Cited by 689 · see citing works

Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo

Wang, X., Lou, N., Xu, Q., Tian, G.-F., Peng, W. G., Han, X., Kang, J., Takano, T., & Nedergaard, M. (2006) · Nature Neuroscience · doi:10.1038/nn1703 · Cited by 685 · see citing works

Trophic Interactions Between Astroglial Cells and Hippocampal Neurons in Culture

Banker, G. A. (1980) · Science · doi:10.1126/science.7403847 · Cited by 674 · see citing works

Glial Cells Dilate and Constrict Blood Vessels: A Mechanism of Neurovascular Coupling

Metea, M. R., & Newman, E. A. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4048-05.2006 · Cited by 637 · see citing works

Tuned Responses of Astrocytes and Their Influence on Hemodynamic Signals in the Visual Cortex

Schummers, J., Yu, H., & Sur, M. (2008) · Science · doi:10.1126/science.1156120 · Cited by 632 · see citing works

Energy metabolism in astrocytes: High rate of oxidative metabolism and spatiotemporal dependence on glycolysis/glycogenolysis

Hertz, L., Peng, L., & Dienel, G. A. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600343 · Cited by 587 · see citing works

What Is the Role of Astrocyte Calcium in Neurophysiology?

Agulhon, C., Petravicz, J., McMullen, A. B., Sweger, E. J., Minton, S. K., Taves, S., Casper, K. B., Fiacco, T. A., & McCarthy, K. D. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.004 · Cited by 567 · see citing works

Regulated ATP release from astrocytes through lysosome exocytosis

Zhang, Z., Chen, G., Zhou, W., Song, A., Xu, T., Luo, Q., Wang, W., Gu, X., & Duan, S. (2007) · Nature Cell Biology · doi:10.1038/ncb1620 · Cited by 525 · see citing works

The Transcriptome and Metabolic Gene Signature of Protoplasmic Astrocytes in the Adult Murine Cortex

Lovatt, D., Sonnewald, U., Waagepetersen, H. S., Schousboe, A., He, W., Lin, J. H.-C., Han, X., Takano, T., Wang, S., Sim, F. J., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3404-07.2007 · Cited by 488 · see citing works

Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease

Lobsiger, C. S., & Cleveland, D. W. (2007) · Nature Neuroscience · doi:10.1038/nn1988 · Cited by 438 · see citing works

Transcriptional profiling reveals evidence for signaling and oligodendroglial abnormalities in the temporal cortex from patients with major depressive disorder

Aston, C., Jiang, L., & Sokolov, B. P. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001565 · Cited by 427 · see citing works

Neuregulin-1/ErbB Signaling Serves Distinct Functions in Myelination of the Peripheral and Central Nervous System

Brinkmann, B. G., Agarwal, A., Sereda, M. W., Garratt, A. N., Müller, T. H., Wende, H., Stassart, R. M., Nawaz, S., Humml, C., Velanac, V., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.028 · Cited by 419 · see citing works

The transcriptome of retinal Müller glial cells

Roesch, K., Jadhav, A. P., Trimarchi, J. M., Stadler, M. B., Roska, B., Sun, B. B., & Cepko, C. L. (2008) · The Journal of Comparative Neurology · doi:10.1002/cne.21730 · Cited by 409 · see citing works

Tumor Necrosis Factor-α Mediates One Component of Competitive, Experience-Dependent Plasticity in Developing Visual Cortex

Kaneko, M., Stellwagen, D., Malenka, R. C., & Stryker, M. P. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.023 · Cited by 405 · see citing works

Absence of C1q Leads to Less Neuropathology in Transgenic Mouse Models of Alzheimer's Disease

Fonseca, M. I., Zhou, J., Botto, M., & Tenner, A. J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0901-04.2004 · Cited by 345 · see citing works

Immune signalling in neural development, synaptic plasticity and disease

Boulanger, L. M., & Shatz, C. J. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1428 · Cited by 334 · see citing works

NGF Controls Axonal Receptivity to Myelination by Schwann Cells or Oligodendrocytes

Chan, J. R., Watkins, T. A., Cosgaya, J. M., Zhang, C., Chen, L., Reichardt, L. F., Shooter, E. M., & Barres, B. A. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.024 · Cited by 326 · see citing works

Astrocyte control of the cerebrovasculature

Gordon, G. R., Mulligan, S. J., & MacVicar, B. A. (2007) · Glia · doi:10.1002/glia.20543 · Cited by 323 · see citing works

Gliomedin mediates Schwann cell-axon interaction and the molecular assembly of the nodes of Ranvier

Eshed, Y., Feinberg, K., Poliak, S., Sabanay, H., Sarig-Nadir, O., Spiegel, I., Bermingham, J. R., & Peles, E. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.026 · Cited by 321 · see citing works

Distinct Stages of Myelination Regulated by γ-Secretase and Astrocytes in a Rapidly Myelinating CNS Coculture System

Watkins, T. A., Emery, B., Mulinyawe, S. B., & Barres, B. A. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.011 · Cited by 320 · see citing works

Developmental plasticity of CNS microglia

Santambrogio, L., Belyanskaya, S. L., Fischer, F., Cipriani, B., Brosnan, C. F., Ricciardi‐Castagnoli, P., Stern, L. J., Strominger, J. L., & Riese, R. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111152498 · Cited by 309 · see citing works

Thrombospondins 1 and 2 are Necessary for Synaptic Plasticity and Functional Recovery after Stroke

Liauw, J. A., Hoang, S., Choi, M. Y., Eroğlu, Ç., Choi, M., Sun, G.-H., Percy, M., Wildman‐Tobriner, B., Bliss, T. M., Guzman, R. G., et al. (2008) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2008.65 · Cited by 263 · see citing works

Axon branch removal at developing synapses by axosome shedding.

Bishop, D. L., Misgeld, T., Walsh, M. K., Gan, W.-B., & Lichtman, J. W. (2004) · Neuron · doi:10.1016/j.neuron.2004.10.026 · Cited by 259 · see citing works

Coupling of Neural Activity to Blood Flow in Olfactory Glomeruli Is Mediated by Astrocytic Pathways

Petzold, G. C., Albeanu, D. F., Sato, T. F., & Murthy, V. N. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.029 · Cited by 255 · see citing works

Nervenkitt: Notes on the history of the concept of neuroglia

Somjen, G. G. (1988) · Glia · doi:10.1002/glia.440010103 · Cited by 233 · see citing works

Barriers in the brain: a renaissance?

Saunders, N. R., Ek, C. J., Habgood, M. D., & Dzięgielewska, K. M. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.03.003 · Cited by 226 · see citing works

Ocular dominance plasticity in adult cat visual cortex after transplantation of cultured astrocytes

Müller, C., & Best, J. (1989) · Nature · doi:10.1038/342427a0 · Cited by 218 · see citing works

CD11c/EYFP transgene illuminates a discrete network of dendritic cells within the embryonic, neonatal, adult, and injured mouse brain

Bulloch, K., Miller, M. M., Toth, J. G., Milner, T. A., Gottfried‐Blackmore, A., Waters, E. M., Kaunzner, U. W., Liu, K., Lindquist, R. L., Nussenzweig, M. C., et al. (2008) · The Journal of Comparative Neurology · doi:10.1002/cne.21668 · Cited by 210 · see citing works

Neuron to glia signaling triggers myelin membrane exocytosis from endosomal storage sites

Trajkovic, K., Dhaunchak, A. S., Goncalves, J. T., Wenzel, D., Schneider, A., Bunt, G., Nave, K.-A., & Simons, M. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200509022 · Cited by 186 · see citing works

Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons

Makita, T., Sucov, H. M., Gariepy, C. E., Yanagisawa, M., & Ginty, D. D. (2008) · Nature · doi:10.1038/nature06859 · Cited by 185 · see citing works

Two‐Photon Imaging of Astrocytic Ca2+ Signaling and the Microvasculature in Experimental Mice Models of Alzheimer's Disease

Takano, T., Han, X., Deane, R., Zloković, B. V., & Nedergaard, M. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1379.004 · Cited by 167 · see citing works

The Dark Side of Glia

Miller, G. (2005) · Science · doi:10.1126/science.308.5723.778 · Cited by 153 · see citing works

Ablation of Proliferating Microglia Does Not Affect Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis Caused by Mutant Superoxide Dismutase

Gowing, G., Philips, T., Wijmeersch, B. V., Audet, J., Dewil, M., Bosch, L. V. D., Billiau, A., Robberecht, W., & Julien, J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3494-08.2008 · Cited by 150 · see citing works

Cutting Edge: Central Nervous System Plasmacytoid Dendritic Cells Regulate the Severity of Relapsing Experimental Autoimmune Encephalomyelitis

Bailey-Bucktrout, S. L., Caulkins, S. C., Goings, G. E., Fischer, J. A. A., Dzionek, A., & Miller, S. D. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.10.6457 · Cited by 147 · see citing works

Antigen Presentation in the CNS by Myeloid Dendritic Cells Drives Progression of Relapsing Experimental Autoimmune Encephalomyelitis

MILLER, S. D., McMAHON, E. J., SCHREINER, B., & BAILEY, S. L. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1394.023 · Cited by 144 · see citing works

Lysosomes Are the Major Vesicular Compartment Undergoing Ca2+-Regulated Exocytosis from Cortical Astrocytes

Li, D., Ropert, N., Koulakoff, A., Giaume, C., & Oheim, M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0744-08.2008 · Cited by 143 · see citing works

A genetic screen identifies genes essential for development of myelinated axons in zebrafish.

Pogoda, H.-M., Sternheim, N., Lyons, D., Diamond, B., Hawkins, T. A., Woods, I., Bhatt, D. H., Franzini-armstrong, C., Dominguez, C., Arana, N., et al. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.06.021 · Cited by 135 · see citing works

Neuronal survival depends on EGFR signaling in cortical but not midbrain astrocytes

Wagner, B., Natarajan, A., Grünaug, S., Kroismayr, R., Wagner, E. F., & Sibilia, M. C. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7600988 · Cited by 122 · see citing works

Increased Cortical Expression of Two Synaptogenic Thrombospondins in Human Brain Evolution

Cáceres, M., Suwyn, C. R., Maddox, M., Thomas, J. W., & Preuss, T. M. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhl140 · Cited by 114 · see citing works

A Rose by Any Other Name? The Potential Consequences of Microglial Heterogeneity During CNS Health and Disease

Carson, M. J., Bilousova, T. V., Puntambekar, S. S., Melchior, B., Doose, J. M., & Ethell, I. M. (2007) · Neurotherapeutics · doi:10.1016/j.nurt.2007.07.002 · Cited by 113 · see citing works

Astrocytes, but not olfactory ensheathing cells or Schwann cells, promote myelination of CNS axons in vitro

Sorensen, A., Moffat, K., Thomson, C., & Barnett, S. C. (2008) · Glia · doi:10.1002/glia.20650 · Cited by 107 · see citing works

Purinergic signaling induces thrombospondin-1 expression in astrocytes

Tran, M. D., & Neary, J. T. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603146103 · Cited by 100 · see citing works

A Novel Purification Method for CNS Projection Neurons Leads to the Identification of Brain Vascular Cells as a Source of Trophic Support for Corticospinal Motor Neurons

Dugas, J. C., Mandemakers, W. J., Rogers, M., Ibrahim, A., Daneman, R., & Barres, B. A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2010-08.2008 · Cited by 99 · see citing works

Synaptic communication between neurons and NG2+ cells

Paukert, M., & Bergles, D. E. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2006.08.009 · Cited by 97 · see citing works

Shapes of astrocyte networks in the juvenile brain

Houades, V., Rouach, N., Ezan, P., Kirchhoff, F., Koulakoff, A., & Giaume, C. (2006) · Neuron Glia Biology · doi:10.1017/s1740925x06000081 · Cited by 97 · see citing works

Resolving vesicle fusion from lysis to monitor calcium-triggered lysosomal exocytosis in astrocytes

Jaiswal, J. K., Fix, M., Takano, T., Nedergaard, M., & Simon, S. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704935104 · Cited by 94 · see citing works

Microglia

Soulet, D., & Rivest, S. (2008) · Current Biology · doi:10.1016/j.cub.2008.04.047 · Cited by 90 · see citing works

Injury discharges regulate calcium channel alpha-2-delta-1 subunit upregulation in the dorsal horn that contributes to initiation of neuropathic pain

Boroujerdi, A., Kim, H. K., Lyu, Y.-S., Kim, D.-S., Figueroa, K. W., Chung, J. M., & Luo, D. Z. (2008) · Pain · doi:10.1016/j.pain.2008.05.004 · Cited by 83 · see citing works

The Role of Glial Cells in the Formation and Maintenance of the Neuromuscular Junction

Feng, Z., & Ko, C. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1405.016 · Cited by 74 · see citing works

D-Serine as a putative glial neurotransmitter.

Mustafa, A., Kim, P. M., & Snyder, S. (2004) · Neuron Glia Biology · doi:10.1017/s1740925x05000141 · Cited by 70 · see citing works

Strategies to Circumvent Vascular Barriers of the Central Nervous System

Zloković, B. V., Zloković, B. V., & Apuzzo, M. L. J. (1998) · Neurosurgery · doi:10.1097/00006123-199810000-00089 · Cited by 68 · see citing works

Identification of a Novel Oligodendrocyte Cell Adhesion Protein Using Gene Expression Profiling

Nielsen, J. A., Maric, D., Lau, P., Barker, J. L., & Hudson, L. D. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2246-06.2006 · Cited by 64 · see citing works

Structural and functional organization of the synapse

Hell, J., & Ehlers, M. (2008) · Springer eBooks · doi:10.1007/978-0-387-77232-5 · Cited by 52 · see citing works

Glia as Active Participants in the Development and Function of Synapses

Eroğlu, Ç., Barres, B. A., & Stevens, B. (2008) · Springer eBooks · doi:10.1007/978-0-387-77232-5_23 · Cited by 17 · see citing works

Astrocytes: Biology and pathology

Sofroniew, M. V., & Vinters, H. V. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0619-8 · Cited by 5,196 · see citing works

Microglia Function in the Central Nervous System During Health and Neurodegeneration

Colonna, M., & Butovsky, O. (2017) · Annual Review of Immunology · doi:10.1146/annurev-immunol-051116-052358 · Cited by 2,894 · see citing works

The Glial Nature of Embryonic and Adult Neural Stem Cells

Kriegstein, A., & Alvarez-Buylla, A. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135600 · Cited by 2,475 · see citing works

Interactions between the microbiota, immune and nervous systems in health and disease

Fung, T. C., Olson, C. A., & Hsiao, E. Y. (2017) · Nature Neuroscience · doi:10.1038/nn.4476 · Cited by 1,900 · see citing works

Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways

Chung, W.-S., Clarke, L. E., Wang, G. X., Stafford, B. K., Sher, A., Chakraborty, C., Joung, J., Foo, L. C., Thompson, A., Chen, C., et al. (2013) · Nature · doi:10.1038/nature12776 · Cited by 1,377 · see citing works

Astrocyte barriers to neurotoxic inflammation

Sofroniew, M. V. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3898 · Cited by 1,202 · see citing works

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease

Guo, T., Zhang, D., Zeng, Y., Huang, T. Y., Xu, H., & Zhao, Y. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00391-7 · Cited by 994 · see citing works

Astrocyte reactivity and reactive astrogliosis: costs and benefits

Pekny, M., & Pekna, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00041.2013 · Cited by 934 · see citing works

Oligodendrocytes: biology and pathology

Bradl, M., & Lassmann, H. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0601-5 · Cited by 933 · see citing works

Cell type- and brain region-resolved mouse brain proteome

Sharma, K., Schmitt, S., Bergner, C. G., Tyanova, S., Kannaiyan, N., Manrique-Hoyos, N., Kongi, K., Cantuti, L., Hanisch, U.-K., Philips, M.-A., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4160 · Cited by 871 · see citing works

Glia — more than just brain glue

Allen, N. J., & Barres, B. A. (2009) · Nature · doi:10.1038/457675a · Cited by 856 · see citing works

Regulation of synaptic connectivity by glia.

Eroglu, C., & Barres, B. A. (2010) · Nature · doi:10.1038/nature09612 · Cited by 813 · see citing works

GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease

Jo, S., Yarishkin, O., Hwang, Y. J., Chun, Y. E., Park, M., Woo, D. H., Bae, J. Y., Kim, T., Lee, J., Chun, H., et al. (2014) · Nature Medicine · doi:10.1038/nm.3639 · Cited by 783 · see citing works

Identification of region-specific astrocyte subtypes at single cell resolution

Batiuk, M. Y., Martirosyan, A., Wahis, J., de Vin, F., Marneffe, C., Kusserow, C., Koeppen, J., Viana, J. F., Oliveira, J. F., Voet, T., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-14198-8 · Cited by 805 · see citing works

The remarkable, yet not extraordinary, human brain as a scaled-up primate brain and its associated cost

Herculano-Houzel, S. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201895109 · Cited by 726 · see citing works

Neuroinflammation and psychiatric illness

Najjar, S., Pearlman, D. M., Alper, K., Najjar, A., & Devinsky, O. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-43 · Cited by 733 · see citing works

Astrogliosis

Sofroniew, M. V. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020420 · Cited by 695 · see citing works

Early-life programming of later-life brain and behavior: a critical role for the immune system

Bilbo, S. D. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.014.2009 · Cited by 652 · see citing works

Neural recording and modulation technologies

Chen, R., Canales, A., & Anikeeva, P. (2017) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.93 · Cited by 655 · see citing works

Astrocyte–neuron metabolic relationships: for better and for worse

Allaman, I., Bélanger, M., & Magistretti, P. J. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2010.12.001 · Cited by 639 · see citing works

Molecular basis of astrocyte diversity and morphology across the CNS in health and disease

Endo, F., Kasai, A., Soto, J. S., Yu, X., Qu, Z., Hashimoto, H., Gradinaru, V., Kawaguchi, R., & Khakh, B. S. (2022) · Science · doi:10.1126/science.adc9020 · Cited by 560 · see citing works

Glial cells in (patho)physiology

Parpura, V., Heneka, M. T., Montana, V., Oliet, S. H. R., Schousboe, A., Haydon, P. G., Stout, R. F., Spray, D. C., Reichenbach, A., Pannicke, T., et al. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07664.x · Cited by 561 · see citing works

Identification of diverse astrocyte populations and their malignant analogs

John Lin, C.-C., Yu, K., Hatcher, A., Huang, T.-W., Lee, H. K., Carlson, J., Weston, M. C., Chen, F., Zhang, Y., Zhu, W., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4493 · Cited by 525 · see citing works

Neuroinflammation in the pathogenesis of Alzheimer’s disease. A rational framework for the search of novel therapeutic approaches

Morales, I., Guzmán-Martínez, L., Cerda-Troncoso, C., Farías, G. A., & Maccioni, R. B. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00112 · Cited by 490 · see citing works

New Transgenic Mouse Lines for Selectively Targeting Astrocytes and Studying Calcium Signals in Astrocyte Processes In Situ and In Vivo

Srinivasan, R., Lu, T.-Y., Chai, H., Xu, J., Huang, B. S., Golshani, P., Coppola, G., & Khakh, B. S. (2016) · Neuron · doi:10.1016/j.neuron.2016.11.030 · Cited by 443 · see citing works

An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem Cells

TCW, J., Wang, M., Pimenova, A. A., Bowles, K. R., Hartley, B. J., Lacin, E., Machlovi, S. I., Abdelaal, R., Karch, C. M., Phatnani, H., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.06.018 · Cited by 435 · see citing works

Astrocytes in Neurodegenerative Disease: Table 1.

Phatnani, H., & Maniatis, T. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020628 · Cited by 420 · see citing works

Role of Astrocytes in Neurovascular Coupling

Petzold, G. C., & Murthy, V. N. (2011) · Neuron · doi:10.1016/j.neuron.2011.08.009 · Cited by 409 · see citing works

Leukodystrophies: a proposed classification system based on pathological changes and pathogenetic mechanisms

van der Knaap, M. S., & Bugiani, M. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1739-1 · Cited by 403 · see citing works

Inhibition of Stat3‐mediated astrogliosis ameliorates pathology in an Alzheimer's disease model

Reichenbach, N., Delekate, A., Plescher, M., Schmitt, F., Krauss, S., Blank, N., Halle, A., & Petzold, G. C. (2019) · EMBO Molecular Medicine · doi:10.15252/emmm.201809665 · Cited by 343 · see citing works

Dynamics and Mechanisms of CNS Myelination

Bercury, K. K., & Macklin, W. B. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.01.016 · Cited by 320 · see citing works

Gliotransmission: Beyond Black-and-White

Savtchouk, I., & Volterra, A. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.0017-17.2017 · Cited by 325 · see citing works

Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice

Kraft, A. W., Hu, X., Yoon, H., Yan, P., Xiao, Q., Wang, Y., Gil, S. C., Brown, J., Wilhelmsson, U., Restivo, J. L., et al. (2013) · The FASEB Journal · doi:10.1096/fj.12-208660 · Cited by 324 · see citing works

Tonic inhibition in dentate gyrus impairs long-term potentiation and memory in an Alzheimer’s disease model

Wu, Z., Guo, Z., Gearing, M., & Chen, G. (2014) · Nature Communications · doi:10.1038/ncomms5159 · Cited by 306 · see citing works

Glia in mammalian development and disease

Zuchero, J. B., & Barres, B. A. (2015) · Development · doi:10.1242/dev.129304 · Cited by 304 · see citing works

Oligodendroglial myelination requires astrocyte-derived lipids

Camargo, N., Goudriaan, A., van Deijk, A.-L. F., Otte, W. M., Brouwers, J. F., Lodder, H., Gutmann, D. H., Nave, K.-A., Dijkhuizen, R. M., Mansvelder, H. D., et al. (2017) · PLOS Biology · doi:10.1371/journal.pbio.1002605 · Cited by 296 · see citing works

Conservation and divergence of cortical cell organization in human and mouse revealed by MERFISH

Fang, R., Xia, C., Close, J. L., Zhang, M., He, J., Huang, Z., Halpern, A. R., Long, B., Miller, J. A., Lein, E. S., et al. (2022) · Science · doi:10.1126/science.abm1741 · Cited by 277 · see citing works

TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading

Martini-Stoica, H., Cole, A. L., Swartzlander, D. B., Chen, F., Wan, Y.-W., Bajaj, L., Bader, D. A., Lee, V. M. Y., Trojanowski, J. Q., Liu, Z., et al. (2018) · Journal of Experimental Medicine · doi:10.1084/jem.20172158 · Cited by 253 · see citing works

Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: Role of microbiome

Abraham, D., Feher, J., Scuderi, G. L., Szabo, D., Dobolyi, A., Cservenak, M., Juhasz, J., Ligeti, B., Pongor, S., Gomez-Cabrera, M. C., et al. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2018.12.005 · Cited by 260 · see citing works

Whole-transcriptome brain expression and exon-usage profiling in major depression and suicide: evidence for altered glial, endothelial and ATPase activity

Pantazatos, S. P., Huang, Y.-Y., Rosoklija, G. B., Dwork, A. J., Arango, V, & Mann, J. J. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.130 · Cited by 229 · see citing works

Maintaining genome stability in the nervous system

McKinnon, P. J. (2013) · Nature Neuroscience · doi:10.1038/nn.3537 · Cited by 229 · see citing works

Inflammatory Mediators Alter the Astrocyte Transcriptome and Calcium Signaling Elicited by Multiple G-Protein-Coupled Receptors

Hamby, M. E., Coppola, G., Ao, Y., Geschwind, D. H., Khakh, B. S., & Sofroniew, M. V. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.1256-12.2012 · Cited by 228 · see citing works

Dysfunctional Calcium and Glutamate Signaling in Striatal Astrocytes from Huntington's Disease Model Mice

Jiang, R., Diaz-Castro, B., Looger, L. L., & Khakh, B. S. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.3693-15.2016 · Cited by 237 · see citing works

Neuronal synapse formation induced by microglia and interleukin 10

Lim, S.-H., Park, E., You, B., Jung, Y., Park, A.-R., Park, S. G., & Lee, J.-R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081218 · Cited by 224 · see citing works

Newly developed reversible MAO-B inhibitor circumvents the shortcomings of irreversible inhibitors in Alzheimer’s disease

Park, J.-H., Ju, Y. H., Choi, J. W., Song, H. J., Jang, B. K., Woo, J., Chun, H., Kim, H. J., Shin, S. J., Yarishkin, O., et al. (2019) · Science Advances · doi:10.1126/sciadv.aav0316 · Cited by 216 · see citing works

Retinal Macroglial Responses in Health and Disease

de Hoz, R., Rojas, B., Ramírez, A. I., Salazar, J. J., Gallego, B. I., Triviño, A., & Ramírez, J. M. (2016) · BioMed Research International · doi:10.1155/2016/2954721 · Cited by 187 · see citing works

Dysregulated neuronal–microglial cross-talk during aging, stress and inflammation

Jurgens, H. A., & Johnson, R. W. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2010.11.014 · Cited by 179 · see citing works

AMPA receptors as drug targets in neurological disease—advantages, caveats, and future outlook

Chang, P. K. ‐., Verbich, D., & McKinney, R. A. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08165.x · Cited by 155 · see citing works

Neuronal Transgene Expression in Dominant-Negative SNARE Mice

Fujita, T., Chen, M. J., Li, B., Smith, N. A., Peng, W., Sun, W., Toner, M. J., Kress, B. T., Wang, L., Benraiss, A., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.2585-14.2014 · Cited by 141 · see citing works

Physical exercise enhances cognitive flexibility as well as astrocytic and synaptic markers in the medial prefrontal cortex

Brockett, A. T., LaMarca, E. A., & Gould, E. (2015) · PLoS ONE · doi:10.1371/journal.pone.0124859 · Cited by 142 · see citing works

Aging causes morphological alterations in astrocytes and microglia in human substantia nigra pars compacta

Jyothi, H. J., Vidyadhara, D. J., Mahadevan, A., Philip, M., Parmar, S. K., Manohari, S. G., Shankar, S. K., Raju, T. R., & Alladi, P. A. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.08.024 · Cited by 139 · see citing works

Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1

Tripathi, P., Rodriguez-Muela, N., Klim, J. R., de Boer, A. S., Agrawal, S., Sandoe, J., Lopes, C. S., Ogliari, K. S., Williams, L. A., Shear, M., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.06.008 · Cited by 123 · see citing works

Pyruvate kinase and aspartate-glutamate carrier distributions reveal key metabolic links between neurons and glia in retina

Lindsay, K. J., Du, J., Sloat, S. R., Contreras, L., Linton, J. D., Turner, S. J., Sadilek, M., Satrústegui, J., & Hurley, J. B. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1412441111 · Cited by 131 · see citing works

Role of glial cells in the formation and maintenance of synapses

Pfrieger, F. W. (2010) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.11.002 · Cited by 124 · see citing works

Engulfment of cerebral apoptotic bodies controls the course of prion disease in a mouse strain–dependent manner

Kranich, J., Krautler, N. J., Falsig, J., Ballmer, B., Li, S., Hutter, G., Schwarz, P., Moos, R., Julius, C., Miele, G., et al. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20092401 · Cited by 110 · see citing works

Cognitive reserve, cortical plasticity and resistance to Alzheimer's disease

Esiri, M. M., & Chance, S. A. (2012) · Alzheimer's Research & Therapy · doi:10.1186/alzrt105 · Cited by 95 · see citing works

Astrocyte Support for Oligodendrocyte Differentiation can be Conveyed via Extracellular Vesicles but Diminishes with Age

Willis, C. M., Nicaise, A. M., Bongarzone, E. R., Givogri, M., Reiter, C. R., Heintz, O., Jellison, E. R., Sutter, P. A., TeHennepe, G., Ananda, G., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-57663-x · Cited by 76 · see citing works

Nanomicellar formulation of coenzyme Q10 (Ubisol-Q10) effectively blocks ongoing neurodegeneration in the mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model: potential use as an adjuvant treatment in Parkinson's disease

Sikorska, M., Lanthier, P., Miller, H., Beyers, M., Sodja, C., Zurakowski, B., Gangaraju, S., Pandey, S., & Sandhu, J. K. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.03.032 · Cited by 70 · see citing works

The Role of the Classical Complement Cascade in Synapse Loss During Development and Glaucoma

Rosen, A. M., & Stevens, B. (2010) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4419-5635-4_6 · Cited by 60 · see citing works

Efficient gene delivery and selective transduction of astrocytes in the mammalian brain using viral vectors

Merienne, N., Douce, J. L., Faivre, E., Déglon, N., & Bonvento, G. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00106 · Cited by 58 · see citing works

Niosome-Based Approach for In Situ Gene Delivery to Retina and Brain Cortex as Immune-Privileged Tissues

AL Qtaish, N., Gallego, I., Villate-Beitia, I., Sainz-Ramos, M., López-Méndez, T. B., Grijalvo, S., Eritja, R., Soto-Sánchez, C., Martínez-Navarrete, G., Fernández, E., et al. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12030198 · Cited by 57 · see citing works

Destination Brain: the Past, Present, and Future of Therapeutic Gene Delivery

Joshi, C. R., Labhasetwar, V., & Ghorpade, A. (2017) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-016-9724-3 · Cited by 55 · see citing works

PGC-1α signaling coordinates susceptibility to metabolic and oxidative injury in the inner retina

Guo, X., Dason, E. S., Zanon-Moreno, V., Jiang, Q., Nahirnyj, A., Chan, D., Flanagan, J. G., & Sivak, J. M. (2014) · The American Journal of Pathology · doi:10.1016/j.ajpath.2013.12.012 · Cited by 47 · see citing works

Different Patterns of Neurodegeneration and Glia Activation in CA1 and CA3 Hippocampal Regions of TgCRND8 Mice

Ugolini, F., Lana, D., Nardiello, P., Nosi, D., Pantano, D., Casamenti, F., & Giovannini, M. G. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00372 · Cited by 50 · see citing works

Heads‐up: New roles for the fragile X mental retardation protein in neural stem and progenitor cells

Callan, M. A., & Zarnescu, D. C. (2011) · genesis · doi:10.1002/dvg.20745 · Cited by 39 · see citing works

In vivo evidence of microstructural hypo-connectivity of brain white matter in 22q11.2 deletion syndrome

Raven, E. P., Veraart, J., Kievit, R. A., Genc, S., Ward, I. L., Hall, J., Cunningham, A., Doherty, J., van den Bree, M. B. M., & Jones, D. K. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02178-w · Cited by 21 · see citing works

Single-cell resolution analysis of the crosstalk between chemogenically activated astrocytes and microglia

Philtjens, S., Turnbull, M. T., Thedy, B. P., Moon, Y., & Kim, J. (2020) · doi:10.1101/2020.04.27.064881 · Cited by 7 · see citing works

Which side are you on?

Lin, W., Wilson, T., Wiebe, J., et al. (2006) · doi:10.3115/1596276.1596297 · Cited by 269 · see citing works

Triangles Triply in Perspective

M‘Leod, C., & Milne, W. P. (1909) · Proceedings of the Edinburgh Mathematical Society · doi:10.1017/s001309150003488x

Creative perspective for artists and designers

West, K. R. (1995) · Medical Entomology and Zoology

Results Perspective One : Network Perspective

Bentivegna, T. (2013) · Springer eBooks · doi:10.1007/978-3-658-04579-1_5

Building Better Workplaces through Individual Perspective Taking: A Fresh Look at a Fundamental Human Process

Parker, S. K., Atkins, P. W. B., & Axtell, C. M. (2008) · Wiley eBooks · doi:10.1002/9780470773277.ch5 · Cited by 126 · see citing works