Cited by 38Autophagy in Disease and TherapyNeuroinflammation and Neurodegeneration MechanismsCellular transport and secretion

Lysosomal Functions in Glia Associated with Neurodegeneration

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Kreher, Conlan, Favret, Jacob, Maulik, Malabika, Shin, Daesung·2021·Biomolecules

Abstract

Lysosomes are cellular organelles that contain various acidic digestive enzymes. Despite their small size, they have multiple functions. Lysosomes remove or recycle unnecessary cell parts. They repair damaged cellular membranes by exocytosis. Lysosomes also sense cellular energy status and transmit signals to the nucleus. Glial cells are non-neuronal cells in the nervous system and have an active role in homeostatic support for neurons. In response to dynamic cues, glia use lysosomal pathways for the secretion and uptake of regulatory molecules, which affect the physiology of neighboring neurons. Therefore, functional aberration of glial lysosomes can trigger neuronal degeneration. Here, we review lysosomal functions in oligodendrocytes, astrocytes, and microglia, with emphasis on neurodegeneration.

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  • Some genes whose mutations cause childhood disorders (TRPML1, mucolipidosis IV; VAC14, striatonigral degeneration, childhood-onset) encode proteins that are linked to lysosomal dysfunction in neurodegenerative disease, though no genetic risk factors have been identified in these genes for adult diseases.

    “Additionally, some genes whose mutations cause childhood disorders (TRPML1, mucolipidosis IV; VAC14, striatonigral degeneration, childhood-onset) encode proteins that are linked to lysosomal dysfunction in neurodegenerative disease, though no genetic risk factors have been identified in these genes for adult diseases.92,93”

    From The lysosome and proteostatic stress at the intersection of pediatric neurological disorders and adult neurodegenerative diseases (2025) · cites this paper as [92]

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Authors
Kreher, C., Favret, J., Maulik, M., & Shin, D.
Affiliations
University at Buffalo, State University of New York (US)
Corresponding author
Shin, Daesung
Venue
Biomolecules
Publisher
MDPI AG
Published
2021-03-09
Volume
11
Issue
3
Pages
400
ISSN
2218-273X (ISSN-L)
OpenAlex
W3134166808
Cited by
38
References
152
Citations by year
2026: 6 · 2025: 16 · 2024: 2 · 2023: 5 · 2022: 5 · 2021: 4
FWCI
0.61
Type
journal article
Language
en
Open access
Locations
  • Biomolecules (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Institute of Neurological Disorders and Stroke (NS112327)
Topics
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Keywords
lysosomes, glial cells, neurodegeneration, oligodendrocytes, astrocytes, microglia, membrane repair, exocytosis, lysosomal signaling
MeSH terms
Animals, Astrocytes, Humans, Lysosomes, Neuroglia, Oligodendroglia, Microglia, Neurodegenerative Diseases

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