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Cubic membranes: a legend beyond the Flatland* of cell membrane organization
Open accessAbstract
Cubic membranes represent highly curved, three-dimensional nanoperiodic structures that correspond to mathematically well defined triply periodic minimal surfaces. Although they have been observed in numerous cell types and under different conditions, particularly in stressed, diseased, or virally infected cells, knowledge about the formation and function of nonlamellar, cubic structures in biological systems is scarce, and research so far is restricted to the descriptive level. We show that the “organized smooth endoplasmic reticulum” (OSER; Snapp, E.L., R.S. Hegde, M. Francolini, F. Lombardo, S. Colombo, E. Pedrazzini, N. Borgese, and J. Lippincott-Schwartz. 2003. J. Cell Biol. 163:257–269), which is formed in response to elevated levels of specific membrane-resident proteins, is actually the two-dimensional representation of two subtypes of cubic membrane morphology. Controlled OSER induction may thus provide, for the first time, a valuable tool to study cubic membrane formation and function at the molecular level.
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Cited by
Saranathan, V., Osuji, C. O., Mochrie, S. G. J., Noh, H., Narayanan, S., Sandy, A., Dufresne, E. R., & Prum, R. O. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909616107 · Cited by 506
Snijder, E. J., Limpens, R. W. A. L., de Wilde, A. H., de Jong, A. W. M., Zevenhoven-Dobbe, J. C., Maier, H. J., Faas, F. F. G. A., Koster, A. J., & Bárcena, M. (2020) · PLOS Biology · doi:10.1371/journal.pbio.3000715 · Cited by 477
Fong, C., Le, T., & Drummond, C. J. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15148g · Cited by 338
Oudshoorn, D., Rijs, K., Limpens, R. W. A. L., Groen, K., Koster, A. J., Snijder, E. J., Kikkert, M., & Bárcena, M. (2017) · mBio · doi:10.1128/mbio.01658-17 · Cited by 245
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Kadereit, B., Kumar, P., Wang, W.-J., Miranda, D., Snapp, E. L., Severina, N., Torregroza, I., Evans, T., & Silver, D. L. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708579105 · Cited by 252
Metadata
- Authors
- Almsherqi, Z. A., Kohlwein, S. D., & Deng, Y.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2006-06-19
- Volume
- 173
- Issue
- 6
- Pages
- 839-844
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W1965092619
- Cited by
- 238
- References
- 0
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- green
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- Almsherqi, Z. A., Kohlwein, S. D., & Deng, Y. (2006). Cubic membranes: a legend beyond the Flatland* of cell membrane organization. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200603055
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