The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Differential activation and function of Rho GTPases during Salmonella– host cell interactions
Open accessAbstract
Salmonella enterica, the cause of food poisoning and typhoid fever, has evolved sophisticated mechanisms to modulate Rho family guanosine triphosphatases (GTPases) to mediate specific cellular responses such as actin remodeling, macropinocytosis, and nuclear responses. These responses are largely the result of the activity of a set of bacterial proteins (SopE, SopE2, and SopB) that, upon delivery into host cells via a type III secretion system, activate specific Rho family GTPases either directly (SopE and SopE2) or indirectly (SopB) through the stimulation of an endogenous exchange factor. We show that different Rho family GTPases play a distinct role in Salmonella-induced cellular responses. In addition, we report that SopB stimulates cellular responses by activating SH3-containing guanine nucleotide exchange factor (SGEF), an exchange factor for RhoG, which we found plays a central role in the actin cytoskeleton remodeling stimulated by Salmonella. These results reveal a remarkable level of complexity in the manipulation of Rho family GTPases by a bacterial pathogen.
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Cites
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Rac Downregulates Rho Activity
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Salmonella Interactions with Host Cells: Type III Secretion at Work
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SopB, a protein required for virulence of Salmonella dublin , is an inositol phosphate phosphatase
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Endocytosis unplugged: Multiple ways to enter the cell
Kumari, S., MG, S., & Mayor, S. (2010) · Cell Research · doi:10.1038/cr.2010.19 · Cited by 599
QseC Mediates Salmonella enterica Serovar Typhimurium Virulence In Vitro and In Vivo
Moreira, C. G., Weinshenker, D., & Sperandio, V. (2010) · Infection and Immunity · doi:10.1128/iai.01038-09 · Cited by 195
Global Analysis of Host and Bacterial Ubiquitinome in Response to Salmonella Typhimurium Infection
Fiskin, E., Bionda, T., Dikic, I., & Behrends, C. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.04.015 · Cited by 114
Salmonella–at home in the host cell
Malik-Kale, P., Jolly, C. E., Lathrop, S., Winfree, S., Luterbach, C., & Steele-Mortimer, O. (2011) · Frontiers in Microbiology · doi:10.3389/fmicb.2011.00125 · Cited by 114
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Metadata
- Authors
- Patel, J. C., & Galán, J. E.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2006-10-30
- Volume
- 175
- Issue
- 3
- Pages
- 453-463
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W1965933688
- Cited by
- 276
- References
- 32
- FWCI
- 7.24
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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