The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Vascular endothelial growth factor can signal through platelet-derived growth factor receptors
Open accessAbstract
Vascular endothelial growth factor (VEGF-A) is a crucial stimulator of vascular cell migration and proliferation. Using bone marrow–derived human adult mesenchymal stem cells (MSCs) that did not express VEGF receptors, we provide evidence that VEGF-A can stimulate platelet-derived growth factor receptors (PDGFRs), thereby regulating MSC migration and proliferation. VEGF-A binds to both PDGFRα and PDGFRβ and induces tyrosine phosphorylation that, when inhibited, results in attenuation of VEGF-A–induced MSC migration and proliferation. This mechanism was also shown to mediate human dermal fibroblast (HDF) migration. VEGF-A/PDGFR signaling has the potential to regulate vascular cell recruitment and proliferation during tissue regeneration and disease.
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“(Hung et al., 2005), forming the basis for novel therapeutic ap-”
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Cited by
Mesenchymal Stem Cell Migration and Tissue Repair
Fu, X., Liu, G., Halim, A., Ju, Y., Luo, Q., & Song, G. (2019) · Cells · doi:10.3390/cells8080784 · Cited by 1,044
Mode of action of nintedanib in the treatment of idiopathic pulmonary fibrosis
Wollin, L., Wex, E., Pautsch, A., Schnapp, G., Hostettler, K. E., Stowasser, S., & Kolb, M. (2015) · European Respiratory Journal · doi:10.1183/09031936.00174914 · Cited by 1,005
The roles of vascular endothelial growth factor in bone repair and regeneration
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Inflammation and tumor microenvironments: defining the migratory itinerary of mesenchymal stem cells
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Proteomic Analysis of Microvesicles Derived from Human Mesenchymal Stem Cells
Kim, H.-S., Choi, D.-Y., Yun, S. J., Choi, S.-M., Kang, J. W., Jung, J. W., Hwang, D., Kim, K. P., & Kim, D.-W. (2012) · Journal of Proteome Research · doi:10.1021/pr200682z · Cited by 398
Metadata
- Authors
- Ball, S. G., Shuttleworth, C. A., & Kielty, C. M.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2007-04-30
- Volume
- 177
- Issue
- 3
- Pages
- 489-500
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2128743935
- Cited by
- 276
- References
- 4
- FWCI
- 5.63
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
