The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Localized zones of Rho and Rac activities drive initiation and expansion of epithelial cell–cell adhesion
Open accessAbstract
Spatiotemporal coordination of cell–cell adhesion involving lamellipodial interactions, cadherin engagement, and the lateral expansion of the contact is poorly understood. Using high-resolution live-cell imaging, biosensors, and small molecule inhibitors, we investigate how Rac1 and RhoA regulate actin dynamics during de novo contact formation between pairs of epithelial cells. Active Rac1, the Arp2/3 complex, and lamellipodia are initially localized to de novo contacts but rapidly diminish as E-cadherin accumulates; further rounds of activation and down-regulation of Rac1 and Arp2/3 occur at the contacting membrane periphery, and this cycle repeats as a restricted membrane zone that moves outward with the expanding contact. The cortical bundle of actin filaments dissolves beneath the expanding contacts, leaving actin bundles at the contact edges. RhoA and actomyosin contractility are activated at the contact edges and are required to drive expansion and completion of cell–cell adhesion. We show that zones of Rac1 and lamellipodia activity and of RhoA and actomyosin contractility are restricted to the periphery of contacting membranes and together drive initiation, expansion, and completion of cell–cell adhesion.
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Cites
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Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton
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Directed Actin Polymerization Is the Driving Force for Epithelial Cell–Cell Adhesion
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Deconstructing the Cadherin-Catenin-Actin Complex
Yamada, S., Pokutta, S., Drees, F., Weis, W. I., & Nelson, W. J. (2005) · Cell · doi:10.1016/j.cell.2005.09.020 · Cited by 1,021
Self-citationMyosin-dependent junction remodelling controls planar cell intercalation and axis elongation
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Drees, F., Pokutta, S., Yamada, S., Nelson, W. J., & Weis, W. I. (2005) · Cell · doi:10.1016/j.cell.2005.09.021 · Cited by 985
Self-citationE-cadherin null mutant embryos fail to form a trophectoderm epithelium.
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Rac Downregulates Rho Activity
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Collective cell migration in morphogenesis, regeneration and cancer
Friedl, P., & Gilmour, D. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2720 · Cited by 2,712
Adherens junctions: from molecules to morphogenesis
Harris, T. J. C., & Tepass, U. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2927 · Cited by 990
The many faces of actin: matching assembly factors with cellular structures
Chhabra, E. S., & Higgs, H. N. (2007) · Nature Cell Biology · doi:10.1038/ncb1007-1110 · Cited by 744
Spatial organization of the extracellular matrix regulates cell–cell junction positioning
Tseng, Q., Duchemin-Pelletier, E., Deshiere, A., Balland, M., Guillou, H., Filhol, O., & Théry, M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106377109 · Cited by 594
Cell-ECM traction force modulates endogenous tension at cell–cell contacts
Maruthamuthu, V., Sabass, B., Schwarz, U. S., & Gardel, M. L. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011123108 · Cited by 520
Metadata
- Authors
- Yamada, S., & Nelson, W. J.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2007-07-23
- Volume
- 178
- Issue
- 3
- Pages
- 517-527
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2098410928
- Cited by
- 465
- References
- 51
- FWCI
- 11.28
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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