The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Spatial organization of the extracellular matrix regulates cell–cell junction positioning
Open accessAbstract
The organization of cells into epithelium depends on cell interaction with both the extracellular matrix (ECM) and adjacent cells. The role of cell–cell adhesion in the regulation of epithelial topology is well-described. ECM is better known to promote cell migration and provide a structural scaffold for cell anchoring, but its contribution to multicellular morphogenesis is less well-understood. We developed a minimal model system to investigate how ECM affects the spatial organization of intercellular junctions. Fibronectin micropatterns were used to constrain the location of cell–ECM adhesion. We found that ECM affects the degree of stability of intercellular junction positioning and the magnitude of intra- and intercellular forces. Intercellular junctions were permanently displaced, and experienced large perpendicular tensional forces as long as they were positioned close to ECM. They remained stable solely in regions deprived of ECM, where they were submitted to lower tensional forces. The heterogeneity of the spatial organization of ECM induced anisotropic distribution of mechanical constraints in cells, which seemed to adapt their position to minimize both intra- and intercellular forces. These results uncover a morphogenetic role for ECM in the mechanical regulation of cells and intercellular junction positioning.
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Cites
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Cited by
Bohlen, C. J., Bennett, F. C., Tucker, A. F., Collins, H. Y., Mulinyawe, S. B., & Barres, B. A. (2017) · Neuron · doi:10.1016/j.neuron.2017.04.043 · Cited by 658
Loebel, C., Mauck, R. L., & Burdick, J. A. (2019) · Nature Materials · doi:10.1038/s41563-019-0307-6 · Cited by 402
Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy
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YAP-mediated mechanotransduction tunes the macrophage inflammatory response
Meli, V. S., Atcha, H., Veerasubramanian, P. K., Nagalla, R. R., Luu, T. U., Chen, E. Y., Guerrero-Juarez, C. F., Yamaga, K., Pandori, W., Hsieh, J. Y., et al. (2020) · Science Advances · doi:10.1126/sciadv.abb8471 · Cited by 329
Ray, A., Lee, O., Win, Z., Edwards, R. M., Alford, P. W., Kim, D.-H., & Provenzano, P. P. (2017) · Nature Communications · doi:10.1038/ncomms14923 · Cited by 293
Metadata
- Authors
- Tseng, Q., Duchemin-Pelletier, E., Deshiere, A., Balland, M., Guillou, H., Filhol, O., & Théry, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2012-01-17
- Volume
- 109
- Issue
- 5
- Pages
- 1506-1511
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2120795306
- Cited by
- 594
- References
- 37
- FWCI
- 14.50
- Type
- journal article
- Language
- en
- Open access
- green
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- Tseng, Q., Duchemin-Pelletier, E., Deshiere, A., Balland, M., Guillou, H., Filhol, O., & Théry, M. (2012). Spatial organization of the extracellular matrix regulates cell–cell junction positioning. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1106377109
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