The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
PR-Set7–dependent lysine methylation ensures genome replication and stability through S phase
Open accessAbstract
PR-Set7/SET8 is a histone H4–lysine 20 methyltransferase required for normal cell proliferation. However, the exact functions of this enzyme remain to be determined. In this study, we show that human PR-Set7 functions during S phase to regulate cellular proliferation. PR-Set7 associates with replication foci and maintains the bulk of H4-K20 mono- and trimethylation. Consistent with a function in chromosome dynamics during S phase, inhibition of PR-Set7 methyltransferase activity by small hairpin RNA causes a replicative stress characterized by alterations in replication fork velocity and origin firing. This stress is accompanied by massive induction of DNA strand breaks followed by a robust DNA damage response. The DNA damage response includes the activation of ataxia telangiectasia mutated and ataxia telangiectasia related kinase–mediated pathways, which, in turn, leads to p53-mediated growth arrest to avoid aberrant chromosome behavior after improper DNA replication. Collectively, these data indicate that PR-Set7–dependent lysine methylation during S phase is an essential posttranslational mechanism that ensures genome replication and stability.
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Cites
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
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Chromatin structure and the inheritance of epigenetic information
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Polycomb Group Proteins: Multi-Faceted Regulators of Somatic Stem Cells and Cancer
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PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression.
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“12% (14,508) H4K20me1 ChIP-Seq (M phase) me3 me2 me1 In p ut”
Schotta, G., Sengupta, R., Kubicek, S., Malin, S., Kauer, M., Callén, E., Celeste, A., Pagani, M., Opravil, S., De La Rosa-Velazquez, I. A., et al. (2008) · Genes & Development · doi:10.1101/gad.476008 · Cited by 451
Metadata
- Authors
- Tardat, M., Murr, R., Herceg, Z., Sardet, C., & Julien, E.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2007-12-24
- Volume
- 179
- Issue
- 7
- Pages
- 1413-1426
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2101312003
- Cited by
- 169
- References
- 8
- FWCI
- 4.43
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Tardat, M., Murr, R., Herceg, Z., Sardet, C., & Julien, E. (2007). PR-Set7–dependent lysine methylation ensures genome replication and stability through S phase. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200706179
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