The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse
Open accessAbstract
H4K20 methylation is a broad chromatin modification that has been linked with diverse epigenetic functions. Several enzymes target H4K20 methylation, consistent with distinct mono-, di-, and trimethylation states controlling different biological outputs. To analyze the roles of H4K20 methylation states, we generated conditional null alleles for the two Suv4-20h histone methyltransferase (HMTase) genes in the mouse. Suv4-20h-double-null (dn) mice are perinatally lethal and have lost nearly all H4K20me3 and H4K20me2 states. The genome-wide transition to an H4K20me1 state results in increased sensitivity to damaging stress, since Suv4-20h-dn chromatin is less efficient for DNA double-strand break (DSB) repair and prone to chromosomal aberrations. Notably, Suv4-20h-dn B cells are defective in immunoglobulin class-switch recombination, and Suv4-20h-dn deficiency impairs the stem cell pool of lymphoid progenitors. Thus, conversion to an H4K20me1 state results in compromised chromatin that is insufficient to protect genome integrity and to process a DNA-rearranging differentiation program in the mouse.
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Self-citationHistone H4-K16 Acetylation Controls Chromatin Structure and Protein Interactions
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Loss of the Suv39h Histone Methyltransferases Impairs Mammalian Heterochromatin and Genome Stability
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Self-citationA silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin
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The Polycomb-Group Gene Ezh2 Is Required for Early Mouse Development
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Heterochromatin: Guardian of the Genome
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Metadata
- Authors
- Schotta, G., Sengupta, R., Kubicek, S., Malin, S., Kauer, M., Callén, E., Celeste, A., Pagani, M., Opravil, S., De La Rosa-Velazquez, I. A., Espejo, A., Bedford, M. T., Nussenzweig, A., Busslinger, M., & Jenuwein, T.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2008-08-01
- Volume
- 22
- Issue
- 15
- Pages
- 2048-2061
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2127261230
- Cited by
- 451
- References
- 55
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Schotta, G., Sengupta, R., Kubicek, S., Malin, S., Kauer, M., Callén, E., Celeste, A., Pagani, M., Opravil, S., De La Rosa-Velazquez, I. A., Espejo, A., Bedford, M. T., Nussenzweig, A., Busslinger, M., & Jenuwein, T. (2008). A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes & Development. https://doi.org/10.1101/gad.476008
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
