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Rac1 accumulates in the nucleus during the G2 phase of the cell cycle and promotes cell division
Open accessAbstract
Rac1 regulates a wide variety of cellular processes. The polybasic region of the Rac1 C terminus functions both as a plasma membrane–targeting motif and a nuclear localization sequence (NLS). We show that a triproline N-terminal to the polybasic region contributes to the NLS, which is cryptic in the sense that it is strongly inhibited by geranylgeranylation of the adjacent cysteine. Subcellular fractionation demonstrated endogenous Rac1 in the nucleus and Triton X-114 partition revealed that this pool is prenylated. Cell cycle–blocking agents, synchronization of cells stably expressing low levels of GFP-Rac1, and time-lapse microscopy of asynchronous cells revealed Rac1 accumulation in the nucleus in late G2 and exclusion in early G1. Although constitutively active Rac1 restricted to the cytoplasm inhibited cell division, activated Rac1 expressed constitutively in the nucleus increased the mitotic rate. These results show that Rac1 cycles in and out of the nucleus during the cell cycle and thereby plays a role in promoting cell division.
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RHO GTPASES: Biochemistry and Biology
Jaffe, A. B., & Hall, A. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.020604.150721 · Cited by 3,009
Receptor Activation Alters Inner Surface Potential During Phagocytosis
Yeung, T., Terebiznik, M., Yu, L., Silvius, J., Abidi, W. M., Philips, M., Levine, T., Kapus, A., & Grinstein, S. (2006) · Science · doi:10.1126/science.1129551 · Cited by 329
Self-citation
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Metadata
- Authors
- Michaelson, D., Abidi, W., Guardavaccaro, D., Zhou, M., Ahearn, I., Pagano, M., & Philips, M. R.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2008-04-28
- Volume
- 181
- Issue
- 3
- Pages
- 485-496
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2036164824
- Cited by
- 184
- References
- 2
- FWCI
- 5.09
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Michaelson, D., Abidi, W., Guardavaccaro, D., Zhou, M., Ahearn, I., Pagano, M., & Philips, M. R. (2008). Rac1 accumulates in the nucleus during the G2 phase of the cell cycle and promotes cell division. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200801047
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