The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation
Open accessAbstract
Decreased expression of specific microRNAs (miRNAs) occurs in human tumors, which suggests a function for miRNAs in tumor suppression. Herein, levels of the miR-17-5p/miR-20a miRNA cluster were inversely correlated to cyclin D1 abundance in human breast tumors and cell lines. MiR-17/20 suppressed breast cancer cell proliferation and tumor colony formation by negatively regulating cyclin D1 translation via a conserved 3′ untranslated region miRNA-binding site, thereby inhibiting serum-induced S phase entry. The cell cycle effect of miR-17/20 was abrogated by cyclin D1 siRNA and in cyclin D1–deficient breast cancer cells. Mammary epithelial cell–targeted cyclin D1 expression induced miR-17-5p and miR-20a expression in vivo, and cyclin D1 bound the miR-17/20 cluster promoter regulatory region. In summary, these studies identify a novel cyclin D1/miR-17/20 regulatory feedback loop through which cyclin D1 induces miR-17-5p/miR-20a. In turn, miR-17/20 limits the proliferative function of cyclin D1, thus linking expression of a specific miRNA cluster to the regulation of oncogenesis.
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The functions of animal microRNAs
Ambros, V. (2004) · Nature · doi:10.1038/nature02871 · Cited by 10,728
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Combinatorial microRNA target predictions
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A microRNA component of the p53 tumour suppressor network
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An oligonucleotide microchip for genome-wide microRNA profiling in human and mouse tissues
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Specific protection against breast cancers by cyclin D1 ablation
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Cited by
MicroRNA: Biogenesis, Function and Role in Cancer
MacFarlane, L.-A., & R. Murphy, P. (2010) · Current Genomics · doi:10.2174/138920210793175895 · Cited by 1,584
MicroRNAs in Development and Disease
Sayed, D., & Abdellatif, M. (2011) · Physiological Reviews · doi:10.1152/physrev.00006.2010 · Cited by 1,078
Kim, Y.-K., Yu, J., Han, T. S., Park, S.-Y., Namkoong, B., Kim, D. H., Hur, K., Yoo, M.-W., Lee, H.-J., Yang, H.-K., et al. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp002 · Cited by 470
Zhao, W., Geng, D., Li, S., Chen, Z., & Sun, M. (2018) · Cancer Medicine · doi:10.1002/cam4.1353 · Cited by 375
RetractedDoebele, C., Bonauer, A., Fischer, A., Scholz, A., Reiss, Y., Urbich, C., Hofmann, W.-K., Zeiher, A. M., & Dimmeler, S. (2010) · Blood · doi:10.1182/blood-2010-01-264812 · Cited by 362
Metadata
- Authors
- Yu, Z., Wang, C., Wang, M., Li, Z., Casimiro, M. C., Liu, M., Wu, K., Whittle, J., Ju, X., Hyslop, T., McCue, P., & Pestell, R. G.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2008-08-11
- Volume
- 182
- Issue
- 3
- Pages
- 509-517
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2128559716
- Cited by
- 363
- References
- 6
- FWCI
- 10.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Yu, Z., Wang, C., Wang, M., Li, Z., Casimiro, M. C., Liu, M., Wu, K., Whittle, J., Ju, X., Hyslop, T., McCue, P., & Pestell, R. G. (2008). A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200801079
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