The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity
Open accessAbstract
The osteoblast-secreted molecule osteocalcin favors insulin secretion, but how this function is regulated in vivo by extracellular signals is for now unknown. In this study, we show that leptin, which instead inhibits insulin secretion, partly uses the sympathetic nervous system to fulfill this function. Remarkably, for our purpose, an osteoblast-specific ablation of sympathetic signaling results in a leptin-dependent hyperinsulinemia. In osteoblasts, sympathetic tone stimulates expression of Esp, a gene inhibiting the activity of osteocalcin, which is an insulin secretagogue. Accordingly, Esp inactivation doubles hyperinsulinemia and delays glucose intolerance in ob/ob mice, whereas Osteocalcin inactivation halves their hyperinsulinemia. By showing that leptin inhibits insulin secretion by decreasing osteocalcin bioactivity, this study illustrates the importance of the relationship existing between fat and skeleton for the regulation of glucose homeostasis.
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Cites
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Self-citationLeptin Inhibits Bone Formation through a Hypothalamic Relay
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Self-citationLeptin Regulates Bone Formation via the Sympathetic Nervous System
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ResultDifferential Effects of Interleukin-6 and -10 on Skeletal Muscle and Liver Insulin Action In Vivo
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Cited by
Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism
Ferron, M., Wei, J., Yoshizawa, T., Del Fattore, A., DePinho, R. A., Teti, A., Ducy, P., & Karsenty, G. (2010) · Cell · doi:10.1016/j.cell.2010.06.003 · Cited by 1,123
Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition
Fulzele, K., Riddle, R. C., DiGirolamo, D. J., Cao, X., Wan, C., Chen, D., Faugere, M.-C., Aja, S., Hussain, M. A., Brüning, J. C., et al. (2010) · Cell · doi:10.1016/j.cell.2010.06.002 · Cited by 770
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Self-citationNerve Growth Factor Promotes Gastric Tumorigenesis through Aberrant Cholinergic Signaling
Hayakawa, Y., Sakitani, K., Konishi, M., Asfaha, S., Niikura, R., Tomita, H., Renz, B. W., Tailor, Y., Macchini, M., Middelhoff, M., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2016.11.005 · Cited by 573
The contribution of bone to whole-organism physiology
Karsenty, G., & Ferron, M. (2012) · Nature · doi:10.1038/nature10763 · Cited by 537
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Metadata
- Authors
- Hinoi, E., Gao, N., Jung, D. Y., Yadav, V., Yoshizawa, T., Myers, M. G., Chua, S. C., Kim, J. K., Kaestner, K. H., & Karsenty, G.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2008-12-22
- Volume
- 183
- Issue
- 7
- Pages
- 1235-1242
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W1988425215
- Cited by
- 267
- References
- 25
- FWCI
- 21.66
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Hinoi, E., Gao, N., Jung, D. Y., Yadav, V., Yoshizawa, T., Myers, M. G., Chua, S. C., Kim, J. K., Kaestner, K. H., & Karsenty, G. (2008). The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200809113
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